OS Fund

ActiveVenture Capital

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Updated: Jan 22, 2026 ·

Financial History

Total Raised

N/A

Valuation

N/A

Investments Made

Date	Company	Round	Lead Investor(s)	Co-Investor(s)
Oct 1, 2025	QFX	$3.0M Seed	—	General Catalyst, Khosla Ventures, Zachary Sims
Sep 1, 2025	Kernel	$7.0M Seed	—	General Catalyst, Khosla Ventures, Paul Graham
Jul 1, 2025	Stable	$28.0M Seed	—	Acrew Capital, Anthemis Group, In-Q-Tel, LombardStreet Ventures, Notion Capital, Prototype Capital, Range VC, Trucks Venture Capital
Aug 1, 2023	Treehouse	$10.0M Series A	—	Acrew Capital, Anthemis Group, Corazon Capital, In-Q-Tel, Kamay Ventures, LombardStreet Ventures, Maven Ventures, Montage Ventures, Notion Capital, OurCrowd, Prototype Capital, Range VC, Trucks Venture Capital, Preetha Parthasarathy
Jun 1, 2023	Griffin	$14.0M Series A	—	Acrew Capital, Anthemis Group, Armilar Venture Partners, Avaana Capital, Bright Pixel Capital, EQT Ventures, In-Q-Tel, LombardStreet Ventures, MassMutual Ventures, Notion Capital, Prototype Capital, Range VC, Trucks Venture Capital, Kunal Shah
Nov 1, 2022	Anything World	$8.0M Seed	—	Acequia Capital, Acrew Capital, Alumni Ventures, AME Cloud Ventures, Anthemis Group, Antler, Flybridge Capital Partners, Foundry Group, Griffin Gaming Partners, Hardware Club, In-Q-Tel, Kayyak Ventures, LombardStreet Ventures, Notion Capital, Possible Ventures, Prototype Capital, Range VC, Rooks Nest Ventures, SNR, Techstars, Trajectory Ventures, Trucks Venture Capital, Zeroth, Zintinus
Jul 1, 2022	Griffin	$15.0M Venture Round	—	Acrew Capital, Alt Capital, Anthemis Group, Armilar Venture Partners, Bright Pixel Capital, Dragonfly Capital Partners, EQT Ventures, Felicis Ventures, In-Q-Tel, Journey Ventures, LGF, LombardStreet Ventures, Notion Capital, Outrun Ventures, Prototype Capital, Range VC, Trucks Venture Capital, Claire Hughes Johnson, David Petraeus, Gretchen Howard, Henry Kravis, Mathilde Collin, Philippe Teixeira da Mota
Mar 1, 2022	Arzeda	$33.0M Series B	—	IA Ventures, The General Partnership, Louis Beryl
Sep 1, 2021	SingleStore	$80.0M Series F	—	Galaxy Digital, General Catalyst, Insight Partners, Khosla Ventures, Kindred Ventures, NFX, Remagine Ventures, Paul Graham, Zachary Sims
Sep 1, 2021	Aviatrix	$200.0M Series E	—	Eigenspace, Franklin Templeton Investments, General Catalyst, Ignition Partners, Insight Partners, Khosla Ventures, Relay Ventures, TCV, Paul Graham, Zachary Sims
Jul 1, 2021	Acquire.com	$6.0M Seed	—	10100, 2xN, 42Phi Ventures, 8VC, Kevin Hartz, Accel, Acrew Capital, Active Capital, Adapt Ventures, AirAngels, Alliance Healthcare Foundation, Altair Capital Management, Alt Capital, Alumni Ventures, Andreessen Horowitz, Angel investor, AngelList, Anthemis Group, Anti fund, Array Ventures, Audacious Ventures, Authentic Ventures, Awesome People Ventures, Awesome Ventures, Backstage Capital, Bain Capital, Bain Capital Ventures, Base10 (Base10 Partners), TJ Nahigian, Bedrock Capital, Bessemer Venture Partners, Bond, BoxGroup, Brainchild, Breakthrough Energy Ventures, Browder Capital, C2 Investment, Capital Factory, CapitalX, Chemistry VC, Chicago Ventures, Climate Capital, Collab Capital, Color Capital, Comal Ventures, Contrary Capital, Convective Capital, Craft Ventures, Cubit Capital, Cyphr VC, Daffy, Define Ventures, Dell Technologies Capital, Kevin Ding, DOMO Invest, Elephant Partners, Emergent Ventures, Fifth Wall, FirstMark Capital, FJ Labs, Foundation Capital, Founder Collective, Founders Fund, FreshTracks Capital, General Catalyst, Greylock, Harlem Capital, Haystack, Heavybit, Helion Venture Partners, Helium-3 Ventures, Hyde Park Venture Partners, Hyper, IDEO CoLab Ventures, Immeasurable, Include Venture Partners, Infinite Niches, Initialized Capital, In-Q-Tel, Intuition Capital, Investo, Jetstream, JLL Spark, KAAN Ventures, Kepler Operator’s Fund, Kima Ventures, LAUNCH, Lightspeed Venture Partners, LocalGlobe, Locus Ventures, Logos Labs, LOI Venture, LombardStreet Ventures, Long Journey Ventures, M13, M34 Capital, Mucker Capital, Musha Ventures, NewMe Accelerator, NextView Ventures, Not Boring Capital, Notion Capital, Offline Ventures, Operator Collective, Anh-Tho Chuong Degroote, Outcast Ventures, Outlander Labs, Paradigm, Paradox Capital, Pareto Holdings, Pioneer Fund, Point72 Ventures, Positive Sum VC, Practical Venture Capital, Predictive VC, Proton Enterprises, Prototype Capital, Quartz, Rainfall Ventures, Range VC, RareBreed Ventures, Ravelin Capital, Redpoint Ventures, REMUS Capital, Rising Tide Partners, SaaSholic Fund, Saga, SailPoint, Sandalphon Capital, Scale Asia Ventures, Sequoia Capital, Shaan's All Access Fund, Share Ventures, Shield Capital, Shrug Capital, Silence, Slow Ventures, SNR, Soma Capital, SRB Ventures, Starship Ventures, TechSquare Labs, Techstars, The Club, The Hit Forge, Thirty Five Ventures, Todd and Rahul's Angel Fund, Trajectory Ventures, Tribe Capital, Trucks Venture Capital, Trust Fund, Twenty Two Ventures, Uncork Capital, Upfront Ventures, Upside Partnership, Venrock, Vertical Venture Partners, Vibe Capital, Victress Capital, Alex Rodriguez, Weekend Fund, WorkLife Ventures, Y Combinator, York IE, Aaron Skonnard, Adam Guild, Alex Lieberman, Anthony Pompliano, Babak Nivi, Baron Davis, Ben Tossell, Bryce Hall, Catherine Wood, Chris Herd, Chris Murphy, Cory Levy, Daniel Kan, Dharmesh Shah, Dylan Field, Eric Rea, Evan Moore, Frederic Kerrest, Gabriel Jarrosson, Greg Isenberg, Griffin Johnson, Harry Hurst, Ian Hogarth, Immad Akhund, Jaime Schmidt, James Park, Jesse Leimgruber, Jonathan Wasserstrum, Joshua Webster, Julian Shapiro, Justin Mateen, Justin Welsh, Karim Atiyeh, Keith Masback, Kevin Hart, Kunal Shah, Kyle Vogt, Kyle York, Larry Gadea, Marc Benioff, Marcy Simon, Mark Benning, Mathilde Collin, Matt Bellamy, Matt Gibstein, Matthew Dellavedova, Max Mullen, Moshe Lifschitz, Musaab Hakami, Nate Cavanaugh, Paulo Silveira, Paul Yacoubian, Priyank Chandra, Quinn Slack, Rajiv Bala, Rich Miner, Ron Pragides, Roxanne Varza, Sahil Lavingia, Sahin Boydas, Sam Altman, Sam Parr, Scott Belsky, Scot Wingo, Siqi Chen, Steve Schlafman, Tony Jamous, Vinay Hiremath, Yumin Choi, Zach Segal, Zack Kanter
Jun 1, 2021	Guest House	$3.0M Seed	—	Acrew Capital, Anthemis Group, In-Q-Tel, LombardStreet Ventures, Notion Capital, Prototype Capital, Range VC, Trucks Venture Capital
Mar 1, 2021	Docker	$23.0M Series B	—	Afore Capital, AME Cloud Ventures, B Capital Group, Bedrock Capital, Benchmark, Coral (Coral Defi), Greylock, Hardware Club, Khosla Ventures, Morado Venture Partners, NEO, Forest Baskett, Redpoint Ventures, Tribe Capital, WGI Group, Bart Swanson, Hadi Partovi, Howard Charney, Kevin Colas, Marc Benioff, Scott Banister, Spencer Kimball
Feb 1, 2021	Ember	$2.0M Seed	—	Acrew Capital, Anthemis Group, In-Q-Tel, Journey Ventures, LombardStreet Ventures, National Grid Partners, Notion Capital, Prototype Capital, Range VC, Trucks Venture Capital
Feb 1, 2021	Aviatrix	$75.0M Series D	—	Eigenspace, General Catalyst, Ignition Partners, Khosla Ventures, Relay Ventures, Paul Graham, Zachary Sims
Jul 1, 2020	Kernel	$53.0M Series C	—	AME Cloud Ventures, B Capital Group, Bedrock Capital, BlueRun Ventures, David Namdar, General Catalyst, Greylock, Hardware Club, IVP, Khosla Ventures, Lightspeed Venture Partners, March Capital, Maven Ventures, Morado Venture Partners, NEO, Resolute Ventures, Sapphire Ventures, Social Capital, Telescope Partners, Bart Swanson, Hadi Partovi, Kevin Colas, Marc Benioff, Noam Bardin, Ran Makavy, Scott Banister, Sudheesh Nair
Oct 1, 2018	DataRobot	$100.0M Series D	—	Accel, Adams Street Partners, Cervin Ventures, Dave Munichiello, Karim Faris, M.G. Siegler, Sangeen Zeb, GV (Google Ventures), IA Ventures, Meritech Capital Partners, Sapphire Ventures, TGM, The General Partnership, Y Combinator, Louis Beryl, MG Siegler, Will Gaybrick
Sep 1, 2018	Cricket Health	$24.0M Series A	—	Amplify Partners, Battery Ventures, Boldstart Ventures, Bow Capital, BoxGroup, Canaan Partners, Cedar Capital Group, Citi Ventures, City Light Capital, HG Ventures, Hitachi Ventures, IA Ventures, Lightspeed Venture Partners, Lux Capital, MS&AD Ventures, Next Play Ventures, Norwest Venture Partners, Oak HC/FT, Plug & Play Ventures, Redpoint Ventures, Gary Benitt, The General Partnership, Theory Ventures, Ultratech Capital Partners, Dan Ciporin, George Hu, Lisha Li, Louis Beryl, Matt Carbonara
Jul 1, 2018	Lygos - Better Materials for Better Products	$16.0M Series B	—	Bloomberg Beta, IA Ventures, Quiet Capital, The General Partnership, Immad Akhund, Samvit Ramadurgam
Jan 1, 2018	Ripple Foods	$65.0M Series C	—	AME Cloud Ventures, B Capital Group, Bedrock Capital, David Namdar, Greylock, GV, Hardware Club, Khosla Ventures, Lux Capital, Morado Venture Partners, NEO, Safar Partners, Bart Swanson, Hadi Partovi, Kevin Colas, Marc Benioff, Scott Banister
Aug 1, 2017	Flip	$300K Seed	—	IA Ventures, The General Partnership
Jul 1, 2017	Arzeda	$12.0M Series A	—	IA Ventures, The General Partnership, Louis Beryl
Dec 1, 2016	Lygos - Better Materials for Better Products	$13.0M Series A	—	Bloomberg Beta, IA Ventures, Leta Capital, Quiet Capital, The General Partnership, Immad Akhund, Jack Levin, Samvit Ramadurgam
Oct 1, 2016	Kernel	$100.0M Venture Round	—	AME Cloud Ventures, B Capital Group, Bedrock Capital, David Namdar, Greylock, Hardware Club, Khosla Ventures, Morado Venture Partners, NEO, Bart Swanson, Hadi Partovi, Kevin Colas, Marc Benioff, Scott Banister
Jul 1, 2016	Ripple Foods	$30.0M Series B	—	AME Cloud Ventures, B Capital Group, Bedrock Capital, Blueberry Ventures, David Namdar, Greylock, GV, Hardware Club, Khosla Ventures, Lux Capital, Morado Venture Partners, NEO, Safar Partners, Bart Swanson, Hadi Partovi, Kevin Colas, Marc Benioff, Scott Banister

Financial History

Total Raised

N/A

Valuation

N/A

Leadership Team

Key people at OS Fund.

Co-Founder & General Partner

Mark Ghobrial

Partner

Leadership Team

Key people at OS Fund.

Co-Founder & General Partner

Mark Ghobrial

Partner

Deep Dive

High-Level Overview

OS Fund is an American venture capital firm that invests primarily in early-stage science and technology companies focused on breakthrough discoveries in genomics, synthetic biology, computationally derived therapeutics, advanced materials, and diagnostics. Its mission centers on supporting entrepreneurs who are developing foundational platform technologies with the potential to transform industries and improve humanity’s future. The fund emphasizes computationally driven companies leveraging artificial intelligence and machine learning to accelerate innovation. OS Fund has significantly impacted the startup ecosystem by filling a gap left by traditional venture capital firms reluctant to invest in deep science ventures, thereby fostering growth in emerging scientific fields[1][2][5].

Origin Story

OS Fund was founded in 2014 by Bryan Johnson, who committed $100 million from the proceeds of selling his previous company, Braintree, to PayPal. Johnson co-leads the fund with Jeff Klunzinger. The fund was created in response to a decline in federal research and development funding and a lack of venture capital interest in science-heavy startups. The name "OS Fund" derives from "operating system," symbolizing the fund’s focus on foundational technologies that serve as platforms for further innovation. Since its inception, OS Fund has evolved to become a key player in financing early-stage companies that blend biology, computation, and materials science[1][2][4].

Core Differentiators

Unique Investment Model: OS Fund targets early-stage companies at the intersection of science and technology, especially those using AI and machine learning to develop platform technologies.
Network Strength: The fund leverages a network of scientific experts and entrepreneurs to support portfolio companies beyond capital, including IP strategy and scientific guidance.
Track Record: With approximately 26 portfolio companies and around 18 exits, OS Fund has demonstrated success in nurturing deep tech ventures.
Operating Support: OS Fund provides hands-on support post-investment, helping startups navigate complex scientific and regulatory challenges.
Public Methodology: OS Fund has openly shared its investment evaluation methodology, particularly in synthetic biology, to encourage broader investment in emerging sciences[1][3][5].

Role in the Broader Tech Landscape

OS Fund rides the wave of convergence between biology, computation, and materials science, a trend accelerating due to advances in AI and machine learning. The timing is critical as traditional funding sources retreat from high-risk, long-horizon science ventures, creating a vacuum OS Fund fills. Market forces such as growing demand for precision medicine, sustainable materials, and computational drug discovery favor OS Fund’s portfolio focus. By backing platform technologies, OS Fund influences the broader ecosystem by enabling startups that can spawn entire new industries and scientific paradigms[1][2][4].

Quick Take & Future Outlook

Looking ahead, OS Fund is poised to continue expanding its influence by raising additional capital (noted plans to raise $250 million) to support entrepreneurs tackling global challenges through deep tech innovation. Trends such as AI-driven drug discovery, synthetic biology for sustainable manufacturing, and advanced materials development will shape its investment journey. As these fields mature, OS Fund’s role as an early backer of foundational technologies will likely enhance its reputation and impact, potentially catalyzing a new era of science-driven entrepreneurship that extends well beyond current lifetimes[2][5]. This aligns with the fund’s ethos of partnering with founders who envision transformative futures.

Sources

Frequently Asked Questions

Who founded OS Fund?

OS Fund was founded by Jeffrey Klunzinger (Co-Founder & General Partner).

Frequently Asked Questions

Who founded OS Fund?

OS Fund was founded by Jeffrey Klunzinger (Co-Founder & General Partner).

High-Level Overview

Origin Story

Core Differentiators

Unique Investment Model: OS Fund targets early-stage companies at the intersection of science and technology, especially those using AI and machine learning to develop platform technologies.
Network Strength: The fund leverages a network of scientific experts and entrepreneurs to support portfolio companies beyond capital, including IP strategy and scientific guidance.
Track Record: With approximately 26 portfolio companies and around 18 exits, OS Fund has demonstrated success in nurturing deep tech ventures.
Operating Support: OS Fund provides hands-on support post-investment, helping startups navigate complex scientific and regulatory challenges.
Public Methodology: OS Fund has openly shared its investment evaluation methodology, particularly in synthetic biology, to encourage broader investment in emerging sciences[1][3][5].