415 CAPITAL

High-Level Overview

415 Capital is a Munich-based specialist venture capital firm focused exclusively on breakthrough medical technology (MedTech) innovation. The firm’s mission is to advance life-saving healthcare solutions by investing in early- and clinical-stage companies that are pioneering novel therapies and devices, particularly in cardiovascular and neurovascular disease. 415 Capital’s investment philosophy centers on backing entrepreneurs with transformative technologies, providing not only capital but also strategic guidance and access to a global network of clinical and industry experts. Its portfolio spans Europe, the United States, and Israel, with a strong emphasis on technologies that address unmet clinical needs and improve patient outcomes. Over the past decade, the firm has played a pivotal role in the MedTech startup ecosystem, supporting more than 50 companies and facilitating multiple high-profile exits to major medical device corporations.

Origin Story

Founded in 2018, 415 Capital was established by a team of seasoned healthcare investors led by Frank Groenewegen, David Thompson, and Frederik Groenewegen. The firm’s roots trace back to decades of experience in MedTech investing, with its partners having previously funded and guided numerous successful startups in the sector. The launch of 415 Capital marked a strategic shift toward a more focused, institutional approach to venture capital, with the goal of scaling impact by concentrating on clinical-stage innovations. The firm’s first institutional fund closed in 2020, followed by a second, larger fund in 2025, reflecting strong investor confidence and a growing pipeline of high-potential MedTech opportunities. Over time, 415 Capital has evolved from a regional player to a globally recognized force in MedTech venture capital.

Core Differentiators

• Specialized Focus: 415 Capital is one of the few firms dedicated solely to MedTech, with deep expertise in cardiovascular, neurovascular, neuromodulation, and medical robotics.
• Global Network: The firm leverages a broad network of Key Opinion Leaders, leading hospitals, and clinical research institutions to provide portfolio companies with strategic support and access to clinical validation.
• Proven Track Record: With over 50 MedTech startups funded and multiple successful exits (including sales to Boston Scientific, Edwards Lifesciences, and Medtronic), 415 Capital has demonstrated a consistent ability to generate value for investors and entrepreneurs alike.
• Active Operating Support: Beyond capital, the firm offers hands-on guidance in regulatory strategy, commercialization, and scaling, helping startups navigate the complex MedTech landscape.
• Selective Investment Model: 415 Capital targets minority stakes in companies with novel technologies, typically investing between €1 million and €5 million per transaction, with a focus on clinical-stage assets.

Role in the Broader Tech Landscape

415 Capital is riding the wave of rapid innovation in medical technology, where advances in robotics, artificial intelligence, and minimally invasive therapies are transforming patient care. The timing is particularly favorable as healthcare systems worldwide seek more effective, cost-efficient solutions for chronic diseases like cardiovascular disorders. The firm’s focus on clinical-stage companies positions it at the intersection of scientific discovery and commercialization, helping to bridge the gap between research and real-world impact. By supporting startups that are developing next-generation devices, 415 Capital is not only shaping the future of MedTech but also influencing broader trends in healthcare delivery, patient monitoring, and digital health integration.

Quick Take & Future Outlook

Looking ahead, 415 Capital is poised to deepen its impact as MedTech innovation accelerates and demand for life-saving technologies grows. The firm’s recent expansion with a €150 million second fund signals its ambition to back even more high-potential startups and drive further breakthroughs in cardiovascular and neurovascular care. As the boundaries between medicine, technology, and data continue to blur, 415 Capital’s specialized expertise and global network will be increasingly valuable. The firm’s influence is likely to grow, not just in terms of financial returns but also in its ability to shape the future of healthcare by empowering the next generation of MedTech pioneers.