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§ Public · Menlo Park, CA, USA
Versartis is a technology company.
Versartis is a biotechnology company that develops novel therapeutic proteins for the treatment of endocrine disorders. Its core product, somavaratan (VRS-317), is a long-acting recombinant human growth hormone engineered to address growth hormone deficiency using proprietary XTEN technology. This innovative approach aims to extend the therapeutic protein's half-life, thereby reducing the frequency of injections required for chronic conditions.
The company was founded in December 2008 by Jeffrey Cleland, Mark de Boer, Willem Stemmer, Volker Schellenberger, and Joshua Silverman. Their founding insight centered on the significant burden faced by patients with chronic diseases requiring frequent protein-based injections. The founders, leveraging their collective expertise in biopharmaceutical development, sought to create a more patient-friendly treatment paradigm through advanced protein engineering.
The primary beneficiaries of Versartis's product are pediatric patients diagnosed with growth hormone deficiency, who typically require daily injections. The company's vision is to significantly enhance the quality of life for these individuals by providing a treatment that simplifies disease management, improves treatment adherence, and ultimately leads to better health outcomes by minimizing the disruptive impact of frequent medical interventions.
Versartis has raised $144.0M across 6 funding rounds.
Versartis has raised $144.0M in total across 6 funding rounds.
Versartis is a biopharmaceutical company that developed endocrine therapies, primarily a long-acting form of recombinant human growth hormone for treating growth hormone deficiency and related disorders in pediatric endocrinology.[1] It served the healthcare sector, focusing on patients with endocrine conditions, and aimed to solve the problem of frequent injections required for standard growth hormone treatments by offering a longer-acting alternative.[1] Founded in 2008, the company raised $132M, went public via IPO in 2014, but faced challenges leading to its acquisition and rebranding as Aravive, Inc., a late-stage oncology firm with around 14 employees by later records.[1][2][5]
Versartis was founded on December 10, 2008, in Redwood City, California (with later addresses in Menlo Park, CA, and Houston, TX headquarters noted).[1][2][3] Key details on specific founders are not detailed in available records, but the company emerged in the biotech hub of the Bay Area, building on expertise in recombinant protein engineering for endocrine applications.[1][3] Early traction included advancing its lead product to clinical stages and securing an IPO on March 21, 2014, raising significant capital amid interest in improved growth hormone therapies; however, pivotal setbacks like clinical trial issues led to its 2018 acquisition by Aravive Biologics, shifting focus from endocrinology to oncology.[1][5]
Versartis rode the biotech wave in long-acting biologics during the 2010s, when market forces favored therapies reducing injection burden amid rising pediatric endocrinology needs and competition from players like Novo Nordisk.[1] Timing aligned with post-2008 funding recovery for biopharma IPOs, enabling its 2014 public debut, but clinical failures highlighted risks in Phase 3 for rare diseases.[1] It influenced the ecosystem by pioneering fusion protein tech, now seen in Aravive's oncology pivot—targeting AXL signaling in metastatic cancers, a trend amplified by immuno-oncology booms and needs for resistance-overcoming agents.[4][5] This evolution underscores biotech M&A dynamics, repurposing endocrine platforms for high-stakes oncology amid pressures for survival post-IPO.
Versartis as an independent entity concluded via acquisition, with its legacy enduring in Aravive's oncology pipeline, including Phase 2 assets like batiraxcept for ovarian cancer and durvalumab combos.[4][5] Next steps hinge on Aravive's clinical readouts in metastatic disease, shaped by trends in precision oncology, AXL pathway inhibition, and combo therapies with immunotherapy. Influence may grow if trials succeed, expanding from niche endocrinology to broader cancer survival improvements, potentially via partnerships—echoing its original mission to transform patient therapies through innovative biologics.[5]
Versartis has raised $144.0M across 6 funding rounds. Most recently, it raised $55.0M Series E in February 2014.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Feb 1, 2014 | $55M Series E | — | Samsara BioCapital, Advent Life Sciences, Aisling Capital, NEW Leaf Venture Partners, Sofinnova Investments | Announced |
| Oct 1, 2013 | $20M Series D | Srinivas Akkaraju | Advent Life Sciences, Samsara BioCapital, Advent Venture Partners, Aisling Capital, Amunix, Index Ventures, NEW Leaf Venture Partners | Announced |
| Jul 1, 2013 | $12M Series C | — | Advent Life Sciences, Samsara BioCapital | Announced |
| Jan 1, 2013 | $25M Series C | Anthony SUN | Advent Life Sciences, Samsara BioCapital, Advent Venture Partners, Index Ventures, NEW Leaf Venture Partners | Announced |
| Feb 1, 2011 | $21M Series B | Srinivas Akkaraju | Advent Life Sciences, Samsara BioCapital, Shahzad Malik, Amunix, Kevin Johnson | Announced |
| Jun 2, 2009 | $11M Venture Round | Index Ventures | — | Announced |
Versartis has raised $144.0M in total across 6 funding rounds.
Versartis's investors include Samsara BioCapital, Advent Life Sciences, Aisling Capital, New Leaf Venture Partners, Sofinnova Ventures, Srinivas Akkaraju, Advent Venture Partners, Amunix, Index Ventures, Anthony Sun, Shahzad Malik, Kevin Johnson.