Sigilon Therapeutics is a technology company.
Sigilon Therapeutics has raised $80.0M across 1 funding round.
Sigilon Therapeutics has raised $80.0M in total across 1 funding round.
Sigilon Therapeutics has raised $80.0M in total across 1 funding round.
Sigilon Therapeutics's investors include Flagship Ventures, NanoDimension, OrbiMed, Polaris Partners, Timothy A. Springer.
Sigilon Therapeutics is a biopharmaceutical company developing Shielded Living Therapeutics™ (SLTx), immune-protected engineered human cell implants that provide durable treatment for chronic diseases like type 1 diabetes, hemophilia A, and lysosomal storage disorders such as mucopolysaccharidosis type 1 and Fabry disease.[1][2][3][4] These therapies serve patients with acute and chronic conditions by replacing deficient cells or proteins, solving issues like immune rejection, fibrosis, and the need for frequent injections through biocompatible encapsulation using proprietary Afibromer™ technology.[1][3][4] Originally a preclinical-stage biotech with partnerships like Eli Lilly, Sigilon advanced candidates like SIG-001 (Phase I/II for hemophilia A) and SIG-002 (type 1 diabetes), but as of August 2023, it operates as a subsidiary of Eli Lilly, shifting growth momentum toward integrated R&D within Lilly's ecosystem.[2][4]
Founded in 2015 by Flagship Pioneering in Cambridge, Massachusetts, Sigilon emerged from Flagship's innovation platform to address limitations in cell and gene therapies for chronic diseases.[1][2][3] The idea stemmed from combining advanced cell engineering with biocompatible materials to create "living therapeutics" that evade immune responses without immunosuppression, initially targeting hematologic, endocrine, metabolic, and enzyme deficiency disorders.[1][3] Key early milestones included a 2018 global collaboration with Eli Lilly for type 1 diabetes therapies and European Medicines Agency's Advanced Therapy Medicinal Product (ATMP) designation for SIG-003 in hemophilia that same year, building pivotal preclinical traction.[1][3] Renamed Sigilon Therapeutics, Inc. in June 2017, it went public before becoming a Lilly subsidiary in August 2023.[2]
Sigilon stands out in cell therapy through its SLTx platform, which integrates engineered human cells (differentiated from stem cells for specific indications) with Afibromer™ spheres that shield against immune rejection and fibrosis while allowing nutrient influx and protein efflux.[1][4]
Sigilon rides the cell and gene therapy wave, addressing unmet needs in chronic diseases where intermittent treatments fail, amid rising demand for functional cures in endocrinology, hematology, and rare genetic disorders.[1][2][4] Timing aligns with regulatory advances like EMA's ATMP designation and maturing stem cell tech, fueled by market forces such as aging populations, diabetes prevalence (type 1 focus via Lilly), and hemophilia's high unmet needs.[3][6] As a Flagship Pioneering creation now under Lilly, it influences the ecosystem by pioneering encapsulated "living factories," potentially lowering costs versus personalized therapies and enabling scalable, durable alternatives to infusions.[1][3][4]
Sigilon's trajectory points toward clinical milestones in Lilly-led programs like type 1 diabetes and hemophilia, with Afibromer™'s preclinical promise driving expansion into new indications and non-cell applications.[2][4][6] Trends like AI-optimized cell engineering and combo gene-cell modalities will shape progress, potentially evolving Sigilon into a platform leader for fibrosis-resistant implants amid Big Pharma's biotech integration.[1][3] As a Lilly subsidiary, its influence grows through accelerated commercialization, redefining chronic disease management from reactive dosing to proactive physiology restoration—echoing its founding mission to liberate patients from lifelong burdens.[1][2][4]
Sigilon Therapeutics has raised $80.0M across 1 funding round. Most recently, it raised $80.0M Series B in March 2020.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Mar 1, 2020 | $80.0M Series B | Flagship Ventures, NanoDimension, OrbiMed, Polaris Partners, Timothy A. Springer |