Cytoki Pharma is a technology company.
Cytoki Pharma has raised $45.0M across 1 funding round.
Cytoki Pharma has raised $45.0M in total across 1 funding round.
Cytoki Pharma has raised $45.0M in total across 1 funding round.
Cytoki Pharma's investors include NanoDimension, Seventure Partners, Ysios Capital.
Cytoki Pharma is a clinical-stage biotechnology company developing lipidated IL-22 analogues to treat metabolic diseases like obesity and type 2 diabetes, as well as conditions involving epithelial injury such as inflammatory bowel disease (IBD).[1][2][3] Its lead product, CK-0045, a long-acting IL-22 variant licensed from Novo Nordisk, has shown positive Phase 1 results for safety, tolerability, and cardiometabolic benefits, advancing to Phase 2 trials in 2024 for obesity and type 2 diabetes patients.[2][3][4] The company serves patients with unmet needs in cardiometabolic and inflammatory disorders, addressing limitations of current therapies by promoting healthy weight loss, glucose control, and epithelial repair through IL-22's unique biology.[1][2][4]
Founded in 2019 and headquartered in Søborg, Denmark, Cytoki is led by pharma veterans and backed by investors like Lundbeckfonden BioCapital and Ysios Capital, with a growing preclinical pipeline including oral IL-22 for ulcerative colitis.[1][2][4]
Cytoki Pharma was founded in 2019 by Rasmus Jorgensen, PhD, its current CEO, who brought expertise in IL-22 biology and drug discovery.[1][2] The company emerged from an exclusive license of IL-22 therapeutic variants from Novo Nordisk, enabling development of optimized, lipidated analogues like CK-0045 for metabolic and epithelial injury indications.[2] Early focus centered on harnessing endogenous IL-22 to tackle obesity, type 2 diabetes, and IBD, building on preclinical data showing weight reduction, glucose improvement, and anti-inflammatory effects.[2][4][5]
Pivotal moments include positive Phase 1 data in 2024 (NCT05712876) demonstrating CK-0045's potential beyond weight loss, such as cardiometabolic risk reduction, fueling Phase 2 entry.[2] Preclinical publications in 2025 further validated lipidated IL-22 for IBD models, reinforcing the platform's breadth.[4] Leadership, including CSO Martijn van de Bunt and CDO Anne Louise Kjølbye, comprises industry experts in clinical development, with a board from top VC firms.[1]
Cytoki rides the obesity and cardiometabolic boom, where IL-22 offers differentiation from GLP-1s by enabling healthier weight loss and broader effects like glucose control and tissue protection.[2][4] Timing aligns with post-2024 demand for combo therapies and oral options amid GLP-1 limitations (e.g., muscle loss, GI side effects).[2] Market forces favor it: rising IBD prevalence, metabolic syndrome epidemic, and VC interest in novel biologics, as seen in 2025 funding rounds.[4][6]
It influences biotech by validating IL-22 as a paradigm for epithelial-metabolic links, potentially expanding to combo regimens and inspiring platform plays in regenerative medicine.[1][2]
Cytoki's Phase 2 data for CK-0045 in obesity/type 2 diabetes, expected post-2024, will be pivotal; success could position it for partnerships or Phase 3 by 2026-2027, given 29% PTSR benchmark.[2][3] Preclinical oral IL-22 for IBD advances toward clinic, diversifying beyond metabolism amid GLP-1 evolution toward combos.[4] Trends like multi-agonist therapies and gut-axis drugs will shape it, amplifying IL-22's role in durable outcomes. As a nimble Danish biotech, Cytoki could redefine metabolic care, tying back to its mission of IL-22-driven breakthroughs for unmet needs.[1][2]
Cytoki Pharma has raised $45.0M across 1 funding round. Most recently, it raised $45.0M Series A in May 2021.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| May 1, 2021 | $45.0M Series A | NanoDimension, Seventure Partners, Ysios Capital |