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§ Private Profile · St. Louis, MO, USA
Biotech diagnostics company developing predictive diagnostic tests for immunotherapy in oncology using RNA-expression models.
Cofactor Genomics has raised $21.0M across 2 funding rounds.
Key people at Cofactor Genomics.
Cofactor Genomics was founded in 2015 by Dave Messina (Founder and Chief Operating Officer) and Jarret Glasscock (Founder/CTO).
Cofactor Genomics has raised $21.0M in total across 2 funding rounds.
Based in St. Louis, Missouri, Cofactor Genomics is a biotechnology company that develops predictive diagnostic tests for immunotherapy using RNA-expression models and machine learning to characterize tumor microenvironments. The enterprise operates as a clinical diagnostics provider focused on precision medicine and oncology applications to predict patient responses to targeted cancer treatments. Backed by the startup accelerator Y Combinator, the organization operated with 13 employees during its initial batch program and has since achieved national Medicare reimbursement for its proprietary technology. The executive leadership team brings extensive industry experience from prominent healthcare and biotechnology organizations, including Affymetrix, Cellular Dynamics, and Exact Sciences. Prior to shifting toward clinical diagnostics, the firm historically operated as a contract research organization while building its foundational RNA data assets. Cofactor Genomics was founded in 2015 by Jarret Glasscock and Dave Messina.
Key people at Cofactor Genomics.
Cofactor Genomics is a biotechnology company focused on closing the precision medicine gap by developing predictive diagnostics that leverage RNA data and machine learning. Their flagship product, the OncoPrism assay, creates multidimensional biomarkers that predict patient response to immunotherapy more accurately than traditional single-analyte tests. Serving clinicians, researchers, and pharmaceutical developers, Cofactor’s diagnostics enable better-informed treatment decisions, improving outcomes for cancer patients. The company is gaining momentum through clinical collaborations and trials involving multiple cancer types, positioning itself as a leader in RNA-based precision medicine[1][2][4][6].
Founded in the wake of the Human Genome Project’s success in making high-throughput genome sequencing affordable, Cofactor Genomics was established by a team of genomics veterans who recognized the advantages of RNA analysis over DNA for capturing dynamic biological processes. The idea emerged from the need to improve predictive power in immunotherapy response, addressing the low patient response rates caused by reliance on outdated biomarker methods. Early traction came from building a comprehensive RNA-based platform and securing partnerships with healthcare systems for clinical trials, such as the national PREDAPT trial evaluating OncoPrism[2][3][6].
Cofactor Genomics rides the wave of precision medicine and immuno-oncology, sectors experiencing rapid growth due to advances in genomics and machine learning. The timing is critical as immunotherapies, despite breakthroughs, benefit only a minority of patients, highlighting the urgent need for better predictive diagnostics. By harnessing RNA’s dynamic nature and multidimensional data modeling, Cofactor addresses market demands for more accurate, cost-effective tools that improve clinical trial success and patient outcomes. Their work influences the broader ecosystem by setting new standards for biomarker discovery and precision diagnostics, potentially expanding beyond cancer to other immune-related diseases[2][4][6].
Looking ahead, Cofactor Genomics is poised to expand its diagnostic applications across additional cancer subtypes and immune-related conditions, leveraging ongoing clinical data and regulatory progress. Trends such as increasing adoption of RNA technologies, machine learning in healthcare, and demand for personalized therapies will shape their trajectory. As they deepen clinical validation and scale partnerships, Cofactor’s influence in precision medicine is likely to grow, potentially transforming how immunotherapies are prescribed and improving patient survival rates. Their mission to ensure the right patient receives the right treatment at the right time remains central to their future impact[3][4][6].
Cofactor Genomics has raised $21.0M across 2 funding rounds. Most recently, it raised $18.0M Series A in September 2017.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Sep 1, 2017 | $18M Series A | Mark Siegel | Ascension Ventures, Dcvc (data Collective), Khosla Ventures, Lightspeed Venture Partners, Menlo Ventures, Seventure Partners, Tencent Holdings, Clark Landry, Iselect, Stanford, Wilson Sonsini Goodrich & Rosati, Y Combinator | Announced |
| Jul 1, 2015 | $3M Seed | — | 7percent Ventures, 8090 Industries, Amplify.LA, Andreessen Horowitz, Anorak Ventures, Dcvc (data Collective), Formic Ventures, Founder Collective, Great Oaks Venture Capital, Heavybit, H.I.G. Capital, Jude Gomila Rolling Fund, Khosla Ventures, Krillion Ventures, KRM Interests LLC, Left Lane Capital, Lightspeed Venture Partners, Locus Ventures, Matrix, Momenta Ventures, Paradigm, Pioneer Fund, Preston Werner Ventures, Ridgeline Partners, Romulus Capital, Samsung Next Ventures, Seventure Partners, SLVC, Spark Capital, Tencent Holdings, TWO Sigma Ventures, Woodstock Fund, Y Combinator, TOM Mcinerney | Announced |
Cofactor Genomics was founded in 2015 by Dave Messina (Founder and Chief Operating Officer) and Jarret Glasscock (Founder/CTO).
Cofactor Genomics has raised $21.0M in total across 2 funding rounds.
Cofactor Genomics's investors include Mark Siegel, Ascension Ventures, DCVC (Data Collective), Khosla Ventures, Lightspeed Venture Partners, Menlo Ventures, Seventure Partners, Tencent Holdings, Clark Landry, iSelect, Stanford, Wilson Sonsini Goodrich & Rosati.