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§ Private Profile · San Francisco, CA, USA
AI foundation model developer creating RNA-based models for biotech and pharma, focused on drug discovery and clinical trials.
Key people at Blank Bio.
Blank Bio was founded in 2025 by Ian Shi (Founder) and Philip Fradkin (Founder) and Jonny Hsu (Founder).
Blank Bio is a San Francisco, California-based biotechnology company that develops advanced RNA-based artificial intelligence foundation models designed to decode complex RNA biology. The organization focuses on applying these specialized computational models directly to the pharmaceutical and healthcare sectors to facilitate the discovery of more effective therapeutics. Additionally, the firm utilizes its proprietary technology to enable smarter, data-driven clinical trial designs for drug development pipelines. Currently operating with a lean team of three employees, the early-stage startup is financially backed by the prominent technology accelerator Y Combinator and participated as a member of its Summer 2025 cohort. To support the ongoing development of its biological modeling infrastructure, the enterprise is actively recruiting for multiple specialized engineering positions. Blank Bio was officially founded in 2025 by the entrepreneurial team of Philip Fradkin, Jonny Hsu, and Ian Shi.
Blank Bio was founded in 2025 by Ian Shi (Founder) and Philip Fradkin (Founder) and Jonny Hsu (Founder).
Key people at Blank Bio.
Blank Bio is an AI-driven biotech company specializing in RNA-based foundation models designed to accelerate drug discovery and optimize clinical trials. Their proprietary models predict key RNA properties such as expression and stability, enabling pharmaceutical and biotech companies to design better RNA sequences more efficiently, reducing costly experimental cycles. Their lightweight, high-performance RNA foundation model is already in use by major industry players like Sanofi and GSK, and they collaborate with research institutes to advance RNA biology applications.
For an investment firm perspective, Blank Bio’s mission centers on leveraging AI to transform RNA therapeutics development, focusing on the intersection of machine learning and molecular biology. Their investment philosophy would likely emphasize cutting-edge biotech startups that harness AI for drug discovery, particularly in RNA and mRNA therapeutics. Key sectors include RNA-based drug development, AI-driven biotech platforms, and clinical trial innovation. Their impact on the startup ecosystem involves accelerating RNA therapeutic innovation and enabling smarter, data-driven clinical trial designs, thus reducing time and cost barriers in drug development.
For a portfolio company perspective, Blank Bio builds RNA-specific foundation models that serve pharmaceutical companies, biotech firms, and research institutions working on mRNA therapeutics, CRISPR, and biomarker discovery. They solve the problem of inefficient and costly RNA sequence optimization by simulating experiments computationally, predicting RNA behavior before lab work begins. This approach significantly speeds up R&D pipelines and reduces failure rates. Their growth momentum is demonstrated by adoption from industry leaders and ongoing collaborations with prominent research institutes.
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Blank Bio was founded by Jonny, Ian, and Phil, who bring decades of combined experience applying machine learning to biology in both academia (Ph.D. work at the University of Toronto) and industry (including Recursion Pharmaceuticals, Deep Genomics, and Amazon). The idea emerged from the recognition that RNA sequence optimization is a critical bottleneck in drug discovery, where suboptimal sequences can cost billions. By building foundation models specifically tailored to RNA, they aimed to simulate and predict RNA properties computationally, bypassing the need for exhaustive experimental testing. Early traction includes outperforming 59 competing models and securing partnerships with major pharma companies such as Sanofi and GSK, as well as collaborations with research entities like the Arc Institute.
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Blank Bio rides the wave of AI-driven drug discovery, particularly focusing on the rapidly growing RNA therapeutics market, which has gained prominence due to mRNA vaccines and RNA-based medicines. The timing is critical as pharmaceutical companies increasingly seek computational tools to reduce the high costs and long timelines of drug development. Advances in machine learning, structural biology, and RNA biology converge to create a fertile environment for companies like Blank Bio. Their work influences the broader ecosystem by enabling smarter clinical trials and accelerating RNA drug design, which can lead to more personalized and effective therapies. This aligns with industry trends toward precision medicine and AI-powered biotech innovation.
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Looking ahead, Blank Bio is poised to expand its impact by deepening collaborations with pharma and biotech firms, enhancing its RNA foundation models, and broadening applications into areas like CRISPR therapeutics and biomarker discovery. Trends shaping their journey include the growing adoption of AI in life sciences, increasing investment in RNA-based therapies, and the push for more efficient clinical trials. As the RNA therapeutics field matures, Blank Bio’s influence could evolve from a niche AI tool provider to a foundational platform integral to next-generation drug discovery and development workflows. Their open-source approach may also catalyze broader innovation and community engagement in RNA AI research.
This trajectory ties back to their core mission: transforming RNA drug discovery through AI to enable better drugs and smarter clinical trials, ultimately reducing costs and accelerating patient access to novel therapies.
