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Amgen is a publicly traded biopharmaceutical company in Thousand Oaks, California, that discovers, develops, manufactures, and commercializes advanced human therapeutics for patients facing serious complex illnesses. Led by chief executive officer Robert Bradway, the enterprise operates globally with approximately 26,700 employees and generated over twenty eight billion dollars in revenue during 2023. Its extensive portfolio of prescription biologic medicines primarily addresses oncology, cardiovascular disease, nephrology, and inflammation, featuring widely distributed blockbuster products like Enbrel, Prolia, Repatha, and Otezla. The corporation actively expands its clinical pipeline and market reach through strategic partnerships and large acquisitions, including the massive purchase of rare disease drugmaker Horizon Therapeutics in late 2023. This pioneering biotechnology firm was founded in 1980 by a group of innovators that included William Bowes, Franklin Pitcher Johnson, Winston Salser, and first chief executive George Rathmann.
Key people at Amgen.
Key people at Amgen.
Amgen Inc. (NASDAQ: AMGN) is a leading global biotechnology company that discovers, develops, manufactures, and delivers innovative human therapeutics for patients with serious illnesses.[1][3][5] Founded in 1980, it focuses on four key therapeutic areas—oncology, inflammation, rare disease, and general medicine (including cardiovascular, bone health, hematology, neurology, and nephrology)—with a mission to serve patients by transforming science and biotechnology into therapies that restore health or save lives.[1][4][8] Today, Amgen employs approximately 28,000 people worldwide, operates in over 100 countries, and markets around 40 medicines, pioneering recombinant DNA technology to address unmet medical needs and reduce the societal burden of disease.[3][4][5]
The company's flagship products, like EPOGEN® (epoetin alfa) approved in 1989, revolutionized treatments for anemia in kidney disease patients, establishing Amgen as a biotech powerhouse with blockbuster success.[1][2][3] Its growth stems from a patient-centric vision: unlocking biology's potential through advanced human genetics and molecular biology to create differentiated medicines with significant clinical benefits.[1][5]
Amgen originated on April 8, 1980, in Thousand Oaks, California, as Applied Molecular Genetics Inc. (AMGen), founded by venture capitalists like William K. Bowes and scientists, with George B. Rathmann—dubbed "Mr. Biotech" and former Abbott Laboratories R&D VP—as its first CEO.[1][2][3][6] Rathmann set the scientific direction amid the nascent biotech era, leveraging proximity to UCLA and Caltech for talent.[6]
Early experiments spanned cloning luciferase (earning a 1983 *Science* cover), engineering bacteria for oil extraction or dyes, and accelerating chicken growth, but the pivotal breakthrough came in 1983 when Fu-Kuen Lin's team cloned the erythropoietin (EPO) gene.[2][3][7] This fueled Amgen's 1983 IPO, raising ~$40 million, a name change to Amgen, and FDA approval of EPOGEN® in 1989—its first product after nine years, generating $17 million in initial sales.[1][2][3][6][7] Under leaders like Gordon Binder, Amgen expanded globally, building manufacturing in Puerto Rico (1993) and Europe, growing from 344 employees in 1988 to 3,396 by 1994.[2][3][7]
Amgen stands out in biotechnology through:
Amgen rides the biotech wave of recombinant DNA and molecular biology, transforming it from experimental science in the 1980s into a mature industry producing life-saving biologics for chronic diseases.[4][6] Its timing was ideal: launching amid post-1970s DNA tech advances, EPOGEN®'s 1989 approval validated biotech's commercial viability, influencing rivals and accelerating FDA pathways for biologics.[1][3][7]
Market forces like aging populations, rising chronic illnesses (cancer, inflammation), and demand for targeted therapies favor Amgen, as does its shift from pure R&D to a *Fortune* 500 pharma-like entity while retaining biotech agility.[3][6] It shapes the ecosystem by pioneering scalable manufacturing, mentoring talent near top universities, and proving biotech's economic model—serving millions and reducing disease burdens globally.[5][6]
Amgen's trajectory points to sustained leadership in biotech, with its pipeline targeting "breakaway" medicines in oncology and rare diseases amid trends like precision genetics and AI-driven discovery.[5][9] Expect expansion in neurology and cardiovascular via acquisitions or partnerships, leveraging 45 years of infrastructure to navigate biosimilar competition and regulatory shifts.[3]
As biotech evolves toward personalized therapies, Amgen's patient-first mission—born from 1980s boldness—positions it to unlock biology's full potential, influencing global health by delivering therapies that not only treat but transform lives for serious illnesses.[1][8]
