Affimed is a technology company.
Affimed has raised $32.0M across 1 funding round.
Affimed has raised $32.0M in total across 1 funding round.
Affimed has raised $32.0M in total across 1 funding round.
Affimed's investors include EQT Life Sciences.
Affimed N.V. (Nasdaq: AFMD) is a clinical-stage biopharmaceutical company developing innovative cancer immunotherapies by harnessing the innate immune system through its proprietary ROCK® platform and Innate Cell Engager (ICE®) molecules.[1][2][4] These therapies redirect natural killer (NK) cells and macrophages to target tumor cells, addressing hematologic malignancies and solid tumors in patients with hard-to-treat cancers.[1][2] Key products include Acimtamig (AFM13) for CD30-positive lymphomas (Phase 2 completed), AFM24 for advanced EGFR-expressing cancers (Phase 2a ongoing), and preclinical candidates like AFM28 and AFM32.[1][2] Affimed serves oncology patients globally, solving unmet needs in immunotherapy by differentiating from T-cell-focused approaches with promising early data, such as high response rates in combinations.[1][2] Growth is supported by major partnerships, including a $5B+ deal with Genentech and collaborations with Artiva Biotherapeutics and Roivant Sciences.[1][2]
Affimed was founded in 2000 as a spin-off from the German Cancer Research Centre (DKFZ) in Heidelberg by Melvyn Little, initially focusing on proprietary TandAb antibody technology for tetravalent, bispecific antibodies with superior binding and stability over monoclonal antibodies.[3] The idea emerged from DKFZ research to create novel formats targeting cancer and autoimmune diseases, with early candidates like AFM13 (for Hodgkin's lymphoma, Phase 1) and AFM11 (preclinical for non-Hodgkin's lymphoma).[3] Pivotal moments include the 2014 name change from Affimed Therapeutics B.V. to Affimed N.V., relocation to Mannheim, Germany, and the 2018 Genentech collaboration validating its NK cell engager tech with non-dilutive funding.[1][2][3] Under CEO Adi Hoess and CFO Florian Fischer, it evolved to emphasize the ICE®/ROCK® platform for innate immunity.[1][3]
Affimed stands out in immuno-oncology through these key strengths:
Affimed rides the innate immunity wave in immuno-oncology, shifting from T-cell therapies (e.g., CAR-T) to NK/macrophage engagers amid rising resistance and toxicity issues in solid tumors.[1][2] Timing aligns with surging demand for off-the-shelf immunotherapies, fueled by market forces like aging populations, high unmet needs in hematologic/solid cancers, and Big Pharma interest (e.g., Genentech deal).[1] It influences the ecosystem by pioneering ICE® tech, enabling combos with allogeneic NK cells and bispecifics, and advancing preclinical-to-clinical translation from DKFZ roots, potentially reshaping treatment for 10-20% of cancers unresponsive to current options.[1][3]
Affimed's trajectory hinges on Acimtamig readout milestones, AFM24 Phase 2a progress, and partnership expansions, with potential for approvals in niche lymphomas driving revenue amid cash constraints.[1][2] Trends like AI-optimized bispecifics, NK cell manufacturing advances, and combo regimens will shape it, possibly elevating Affimed as a pure-play innate immunity leader if data sustains high responses.[1] Influence may grow via licensing (e.g., AFM32 with Roivant) or buyouts, tying back to its core promise: unlocking the innate immune system for profound patient impact in a $100B+ oncology market.[1][2]
Affimed has raised $32.0M across 1 funding round. Most recently, it raised $32.0M Series B in April 2007.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Apr 1, 2007 | $32.0M Series B | EQT Life Sciences |