Zumutor Biologics is a technology company.
Zumutor Biologics has raised $4.0M across 1 funding round.
Zumutor Biologics has raised $4.0M in total across 1 funding round.
Zumutor Biologics is a clinical-stage immuno-oncology company developing novel monoclonal antibodies targeting NK cells and the tumor microenvironment to treat solid tumors and lymphomas.[1][2][3] Its lead product, ZM008, is a first-in-class antibody against CLEC2D that received FDA IND clearance in 2023 and entered Phase 1 trials for head and neck squamous cell carcinoma, with manufacturing support from Catalent.[5][6] The company serves cancer patients by addressing unmet needs in innate immunity modulation through glyco-engineered antibodies, with additional pipeline candidates like ZM012 (preclinical lymphoma) and services for antibody discovery partnerships; it has raised ~$21.7M total funding and employs 50-200 people across US and India sites.[2][3][5]
Growth momentum includes GLP tox completion, 250L-scale manufacturing, Pre-IND submission, and promising ex-vivo data showing NK activation and tumor infiltration in xenograft models by 2022, alongside global patents and collaborations.[3]
Zumutor Biologics originated in 2013 in Bangalore, India, with $6M seed funding from Accel Partners, Aarin Capital, IDG Ventures, and KITVEN to build antibody platforms.[1][3] Founders leveraged expertise in antibody engineering and immuno-oncology, developing glyco-engineering, naïve/synthetic display libraries, and early assets like a trastuzumab biosimilar and Exendin-4 by 2014-2015.[3]
In 2015, the company incorporated in the US (initially Cambridge, MA; later Woburn, MA) and raised a $6M Series A from existing investors, filing global patents and expanding to immuno-oncology focus.[1][3] Key milestones include a 2021-2022 round raising $6.2M from Accel, Siana Capital, and Barath Innovation Fund, enabling preclinical advancement of leads like ZM008, plus global licensing of a breast cancer biologic and US/Europe partnerships.[3]
Zumutor rides the NK cell and innate immunity wave in immuno-oncology, shifting from T-cell focus (e.g., checkpoint inhibitors) toward tumor microenvironment modulation amid rising solid tumor resistance.[1][2][6] Timing aligns with post-2020 IO market growth, FDA's fast-track nods for NK therapies, and bispecific/CAR-NK demand, bolstered by their 2023 IND clearance amid ~$100B+ global IO spend.[5]
Market forces favor them: aging populations driving cancer incidence, biotech funding rebound for platforms, and India-US R&D hubs cutting costs. They influence the ecosystem via services accelerating partner pipelines and licensing (e.g., breast cancer biologic), fostering IO innovation in underserved areas like head/neck cancers.[3][5]
Zumutor's Phase 1 ZM008 data readouts (ongoing from 2024 start) could catalyze partnerships or further funding, with combo potential in solid tumors leveraging NK synergies.[5][6] Trends like AI-optimized antibodies and next-gen NK engagers will shape them, potentially expanding to autoimmune via innate immunity platforms.[2]
Their influence may grow through scale-up (post-250L manufacturing) and global deals, solidifying as a bridge between discovery services and proprietary IO assets—echoing their genesis in platform innovation for better biologics.[1][3]
Zumutor Biologics has raised $4.0M in total across 1 funding round.
Zumutor Biologics's investors include Bharat Innovation Fund.
Zumutor Biologics has raised $4.0M across 1 funding round. Most recently, it raised $4.0M Series A in November 2019.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Nov 1, 2019 | $4.0M Series A | Bharat Innovation Fund |