Xilis is a technology company.
Xilis has raised $92.0M across 3 funding rounds.
Xilis has raised $92.0M in total across 3 funding rounds.
Xilis has raised $92.0M in total across 3 funding rounds.
Xilis's investors include Andreessen Horowitz, ARCH Venture Partners, Foresite Capital, FPV Fund, GV, Kleiner Perkins, LGF, Sequoia Capital, Spark Capital, Thrive Capital, Michael Moritz, Sam Altman.
Xilis is a biotechnology company founded in 2019 and headquartered in Durham, North Carolina, specializing in precision oncology through its proprietary MicroOrganoSphere (MOS) technology[1][2][3][5]. The platform builds miniature, patient-derived 3D tumor models that preserve the full cellular composition, heterogeneity, and microenvironment of primary tissues, enabling rapid functional testing of therapies[2][4][5][7]. It serves oncologists by guiding personalized treatment decisions via tools like the Xilis Response Score, improving patient outcomes, and supports pharmaceutical companies in drug discovery, preclinical modeling, high-throughput screening, and clinical trial optimization[1][2][3][4][5]. Xilis addresses the limitations of traditional trial-and-error oncology, where patients endure delays and side effects, by providing scalable, AI-driven predictions of treatment efficacy across modalities like immuno-oncology, chemotherapy, and cell therapies[2][4][5][6]. Growth includes a $70 million Series A raise, expansion to facilities in California and Europe, 78 employees, and ongoing clinical validations, such as a Phase II SBIR trial for HER2+ breast cancer[3][6].
Xilis was co-founded in 2019 by Xiling Shen, Ph.D., who serves as CEO, emerging from his expertise in bioengineering and precision medicine[3]. The idea stemmed from the need to overcome outdated oncology paradigms reliant on trial-and-error, with MOS technology developed as high-fidelity, ex vivo patient avatars—miniature tumors grown rapidly from biopsies to predict responses accurately[1][2][4][6]. Early traction came from investor interest in the U.S. and Europe, securing a $1.75 million SVB venture debt facility to prove the tech, followed by a $70 million Series A that funded lab openings, AI enhancements, clinical studies, and biopharma partnerships[3]. Pivotal moments include automating MOS production via the MODEL platform (FDA, CLIA, IVDR-compliant) and initiating validations like a 50-patient HER2+ breast cancer protocol[3][6].
Xilis rides the precision oncology wave, fueled by advances in AI, single-cell genomics, and patient-derived models amid rising cancer incidence and demands for personalized medicine[1][2][5]. Timing aligns with post-2020 biotech funding surges and regulatory pushes for functional precision tools, as traditional methods fail ~70-90% of patients initially[4][6]. Market forces like pharma's need to cut $2.6B average drug development costs and timelines (10+ years) favor MOS for high-throughput, authentic testing[3][5]. Xilis influences the ecosystem by bridging diagnostics and therapeutics, enabling biopharma efficiencies, clinician empowerment, and faster novel therapies to market, potentially shifting oncology from reactive to predictive[2][4].
Xilis is poised to disrupt oncology with MOS scaling into commercial diagnostics and pharma partnerships, building on Series A momentum toward broader clinical validations and revenue from services[3][6]. Key trends like AI integration, multi-omics, and cell/gene therapies will amplify its platform, especially as trials like HER2+ breast cancer yield data[5][6][7]. Influence may evolve into a standard for functional precision medicine, powering lower-cost trials and better outcomes if MODEL commercializes successfully—transforming the trial-and-error era that sparked its founding into one of patient-matched therapies[4][6].
Xilis has raised $92.0M across 3 funding rounds. Most recently, it raised $19.0M Series A in July 2022.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Jul 1, 2022 | $19.0M Series A | Andreessen Horowitz, ARCH Venture Partners, Foresite Capital, FPV Fund, GV, Kleiner Perkins, LGF, Sequoia Capital, Spark Capital, Thrive Capital, Michael Moritz, Sam Altman | |
| Jul 1, 2021 | $70.0M Series A | Andreessen Horowitz, ARCH Venture Partners, Foresite Capital, FPV Fund, GV, Kleiner Perkins, LGF, Sequoia Capital, Spark Capital, Thrive Capital, Michael Moritz, Sam Altman | |
| Dec 1, 2019 | $3.0M Seed | Andreessen Horowitz, FPV Fund, Kleiner Perkins, LGF, Sequoia Capital, Spark Capital, Thrive Capital, Michael Moritz, Sam Altman |