Visirna Therapeutics is a technology company.
Visirna Therapeutics has raised $60.0M across 1 funding round.
Visirna Therapeutics has raised $60.0M in total across 1 funding round.
Visirna Therapeutics has raised $60.0M in total across 1 funding round.
Visirna Therapeutics's investors include Borealis Ventures, Flagship Ventures, InterWest, Vivo Capital, Wildcat Ventures.
Visirna Therapeutics is a clinical-stage biopharmaceutical company developing small interfering RNA (siRNA) therapeutics targeting cardiovascular and metabolic diseases, with a focus on Greater China.[1][2][4] Formed as a joint venture between Arrowhead Pharmaceuticals and Vivo Capital in 2022, it holds exclusive rights to four of Arrowhead's investigational RNAi medicines—plo zasiran (APOC3 inhibitor for hypertriglyceridemia, Phase 3), zodasiran (ANGPTL3 inhibitor for homozygous familial hypercholesterolemia, Phase 3), VSA-006 (17β-HSD13 inhibitor for nonalcoholic steatohepatitis, Phase 2), and VSA012 (Phase 1 for paroxysmal nocturnal hemoglobinuria)—aiming to build full capabilities in research, manufacturing, and commercialization.[1][3][4][5] Backed by Vivo Capital's $60M initial investment, Visirna serves patients with unmet needs in cardiometabolic disorders, leveraging advanced RNAi technology amid rising disease prevalence and market growth projected through 2032.[3][4]
Visirna Therapeutics emerged in 2022 as a strategic joint venture between Arrowhead Pharmaceuticals (NASDAQ: ARWR), a global leader in RNAi therapeutics, and Vivo Capital, a prominent biotech investor, to bring innovative medicines to Greater China.[1][3][4] Headquartered in Shanghai with a Hong Kong entity, the company secured an exclusive license for four Arrowhead cardiometabolic assets, with Vivo providing $60M upfront and both parties taking equity stakes—Arrowhead as majority shareholder.[4] This partnership built on Arrowhead's advanced pipeline, including Phase 3 programs like the PALISADE trial for ARO-APOC3 (now plozasiran) in familial chylomicronemia syndrome, completed enrollment in 2023.[3] Early momentum includes recruiting management and staff, positioning Visirna for rapid clinical advancement in a region with growing demand for nucleic acid therapies.[4][6]
Visirna rides the explosive growth of RNAi and oligonucleotide therapeutics, a trend accelerating due to successes in lipid-lowering and metabolic treatments amid rising cardiovascular disease burdens in China and Asia.[1][3][7] Timing aligns with maturing siRNA platforms—exemplified by Arrowhead's global progress—and expanding markets like familial chylomicronemia syndrome, valued at $15M in 2022 with strong CAGR forecasts to 2032, driven by higher prevalence awareness and pipeline launches.[3] Favorable forces include China's biotech incentives, international partnerships bridging U.S. innovation to local commercialization, and regulatory tailwinds for imported tech. Visirna influences the ecosystem by localizing advanced therapies, fostering nucleic acid manufacturing in Greater China, and potentially inspiring similar JVs that democratize access to global IP.[4][6]
Visirna is poised for Phase 3 readouts and potential NDA/BLA filings in 2026-2027, with plozasiran and zodasiran leading toward first approvals in hypertriglyceridemia and hypercholesterolemia, while expanding its oligo platform into eye and hematology indications.[1][5][7] Trends like AI-optimized RNAi design, combo therapies for NASH/MASH, and China's self-reliance in biologics will shape its path, amplified by strategic buys to diversify beyond cardiometabolics. Its influence could grow as a regional RNAi hub, scaling from spinout to platform leader—echoing its launch as a bridge for global innovation to Chinese patients.[3][4]
Visirna Therapeutics has raised $60.0M across 1 funding round. Most recently, it raised $60.0M Seed in April 2022.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Apr 1, 2022 | $60.0M Seed | Borealis Ventures, Flagship Ventures, InterWest, Vivo Capital, Wildcat Ventures |