Vaxcyte is a technology company.
Vaxcyte has raised $132.0M across 2 funding rounds.
Vaxcyte has raised $132.0M in total across 2 funding rounds.
Vaxcyte has raised $132.0M in total across 2 funding rounds.
Vaxcyte's investors include RA Capital, Dolby Family Ventures.
Vaxcyte is a clinical-stage biotechnology company developing innovative vaccines to eliminate bacterial infections like invasive pneumococcal disease (IPD), Group A Strep, and Shigella.[1][2] Its lead candidates, VAX-31 (a 31-valent pneumococcal conjugate vaccine, PCV) and VAX-24 (24-valent PCV), target broader protection than existing vaccines like Pfizer's Prevnar 20, serving children, older adults, and high-risk populations by addressing gaps in current coverage—potentially up to 95% for IPD in U.S. adults aged 50+.[1][2][4] The company solves persistent global morbidity from antibiotic-resistant bacteria using a cell-free protein synthesis platform for scalable, high-fidelity vaccines, with strong growth shown by a 115% stock rise over 12 months to a $12 billion market cap after positive Phase 2 data outperforming Prevnar.[4]
Vaxcyte, based in San Carlos, California, emerged from a mission to modernize vaccine development through disruptive biotech, focusing on bacterial diseases with no or inadequate preventives.[3][5][6] Key leaders include Grant Pickering (CEO), Jim Wassil (EVP and COO with 30+ years at Pfizer, Novartis, and Merck launching vaccines like Prevnar 13 and Menveo), and Dr. Hutchinson (EVP with Merck research background in vaccines and infectious diseases).[3] The company has gained early traction via FDA Breakthrough Therapy designation for VAX-31, positive Phase 1/2 data for its PCV franchise, and NIH funding for Shigella work, positioning it as a pre-commercial biotech challenging pneumococcal giants.[1][2][4]
Vaxcyte rides the wave of antimicrobial resistance and demand for next-gen vaccines post-COVID, targeting unmet needs in pneumococcal disease (a top global killer for kids/elderly) where current PCVs leave gaps.[1][2] Timing aligns with rising Shigella/Group A Strep threats and WHO priorities, amplified by its scalable platform amid supply chain strains on traditional manufacturing.[2] It challenges Pfizer's Prevnar dominance—a multi-billion franchise—potentially reshaping standards via superior immunogenicity and coverage, while influencing biotech by proving synthetic vaccine feasibility.[3][4]
Vaxcyte's Phase 3 trials for VAX-31 (adults) and expanding pediatric data position it for potential 2027+ approval, with Breakthrough status accelerating paths.[2][4] Trends like resistance surges and biosecurity focus will propel its pipeline, possibly expanding to more bacteria via the platform. Its influence could evolve from challenger to market leader, redefining PCVs and inspiring synthetic vaccine adoption—echoing its mission to protect every child and at-risk adult from bacterial threats.[1]
Vaxcyte has raised $132.0M across 2 funding rounds. Most recently, it raised $110.0M Series D in March 2020.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Mar 1, 2020 | $110.0M Series D | RA Capital | |
| Jul 1, 2015 | $22.0M Series A | Dolby Family Ventures |