Rush University Medical Center operates as a comprehensive academic health system delivering advanced patient care, conducting vital biomedical research, and educating the next generation of health care professionals. It integrates clinical services with scientific inquiry and medical training, encompassing multiple hospitals and an acclaimed university that supports diverse specialties and treatment approaches. This multidisciplinary structure enables the institution to address complex health challenges and foster innovation across its various disciplines.

The institution's rich history began with the chartering of Rush Medical College in 1837 by Daniel Brainard, named in honor of Benjamin Rush, a prominent physician and signer of the Declaration of Independence. Over time, the college expanded its mission, eventually merging with Presbyterian-St. Luke's Hospital in 1969 to form Rush-Presbyterian-St. Luke's Medical Center. This evolution culminated in its current form as Rush University Medical Center, solidifying its role as a cornerstone of medical advancement in the Chicago area.

Rush serves a broad patient population, dedicated to improving the health of individuals and the diverse communities within its reach. Its long-term vision positions it as a leading academic health system regionally and nationally, continually striving to transform health care delivery and outcomes. Through its commitment to excellence in patient care, education, and research, Rush aims to shape the future of medicine.