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reMYND is a technology company.
reMYND develops first-in-class oral treatments restoring neuronal function for patients with age-related neurodegenerative diseases. The company advances small molecule therapeutics targeting protein misfolding disorders and novel disease mechanisms. Its lead program, REM392, is an orally available small molecule designed to rescue detrimental effects of pathological tau on calcium regulation, addressing Alzheimer's and Parkinson's.
Joris Winderickx, Stefaan Wera, and Fred Leuven founded reMYND in 2002. Their insight highlighted the critical need for disease-modifying treatments directly addressing the underlying protein misfolding mechanisms driving neurodegeneration, moving beyond symptom management. This foundational ambition prioritized direct biological intervention.
reMYND's therapeutics serve individuals affected by various neurodegenerative conditions, including Alzheimer’s, Parkinson’s, and Huntington’s disease. The company's mission is to restore neuronal function and slow disease progression by precisely targeting these mechanisms. They envision delivering effective oral therapeutics to enhance patients' quality of life.
reMYND has raised $28.6M across 2 funding rounds.
reMYND has raised $28.6M in total across 2 funding rounds.
reMYND is a clinical-stage biotechnology company developing first-in-class small molecule therapeutics for neurodegenerative diseases, including Alzheimer's and Huntington's disease.[1][3][4] Its proprietary drug discovery platform identifies novel mechanisms-of-action, targets, and compounds addressing cellular dysfunction in conditions like Alzheimer's, diabetes, epilepsy, and Huntington's.[1][2] The company serves patients with unmet needs in neurodegeneration by targeting synaptic plasticity restoration, tau inhibition, and huntingtin modulation, with lead programs like REM392 (or ReS19-T) in Phase 1 for Alzheimer's, demonstrating safety in single ascending dose (SAD) trials and advancing to multiple ascending dose (MAD).[1][2][4] Growth momentum includes a strategic pivot in recent years to focus solely on drug development after selling its contract research organization (CRO) unit to InnoSer, enabling full commitment to proprietary programs like REM392 for Alzheimer's symptom alleviation and disease modification, and preclinical Huntington's candidates ready for CTA-enabling studies.[2]
Founded in Belgium (headquartered in Heverlee, Flanders), reMYND began with a dual-focus model combining drug discovery and a CRO service arm using proprietary preclinical models for neurodegeneration.[2][5] This structure supported early identification of novel targets and small molecules, building expertise in diseases like Alzheimer's and Parkinson's.[1][2][5] Key leaders include CEO Floor Stam and Chairman Johan Cardoen, who oversaw the strategic transition to a pure drug development organization by integrating the CRO into InnoSer, ensuring continuity of its models for the pharma community while sharpening focus on clinical programs.[2] Pivotal moments include launching the first-in-human trial for ReS19-T (REM392) in Alzheimer's around 2020-2022, advancing to MAD after strong SAD safety data, and preparing Huntington's programs for clinical entry.[1][2][4]
reMYND rides the wave of neurodegeneration therapeutics, targeting the global Alzheimer's market (projected multibillion-dollar opportunity) amid aging populations and failures of amyloid-focused drugs.[1][3] Timing aligns with advances in synaptic and tau biology, where its platform addresses root cellular dysfunction beyond plaques/tangles, influencing the ecosystem by validating novel targets and models now accessible via InnoSer to big pharma and biotechs.[2][5] Market forces like rising neurodegenerative prevalence (e.g., 50M+ dementia cases worldwide) and investor interest in precision small molecules favor reMYND, positioning it to contribute to a shift toward mechanism-based, first-in-class treatments in a sector dominated by biologics.[1][3][4]
reMYND's Phase 1 data for REM392 could catalyze partnerships or funding, with Huntington's programs potentially entering clinic in 2026, accelerating toward proof-of-concept in disease modification.[2][4] Trends like AI-driven discovery and combo therapies will shape its path, amplifying platform scalability for epilepsy/diabetes expansions.[1] Its influence may evolve from niche innovator to ecosystem enabler, delivering patient solutions in desperate need—transforming cellular insights into tangible therapies as promised from its Belgian biotech roots.[2]
reMYND has raised $28.6M in total across 2 funding rounds.
reMYND's investors include BNP Paribas Fortis Private Equity, FPIM, Korys, KU Leuven, PMV.
reMYND has raised $28.6M across 2 funding rounds. Most recently, it raised $14.6M Series B Extension in January 2021.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Jan 21, 2021 | $14.6M Series B Extension | BNP Paribas Fortis Private Equity, FPIM, Korys, KU Leuven, PMV | |
| Dec 1, 2018 | $14.0M Series B |