Purespring Therapeutics is a technology company.
Purespring Therapeutics has raised $170.0M across 2 funding rounds.
Purespring Therapeutics has raised $170.0M in total across 2 funding rounds.
Purespring Therapeutics has raised $170.0M in total across 2 funding rounds.
Purespring Therapeutics's investors include Therese Liechtenstein, Soffinova Partners, Advent Life Sciences.
Purespring Therapeutics is a clinical-stage precision nephrology company developing targeted, first-in-class gene therapies to preserve kidney function and address unmet needs in glomerular kidney diseases.[1][2][3] It builds gene therapies using its proprietary GlomThera™ platform, which delivers AAV-based treatments directly to podocytes—specialized kidney cells implicated in ~60% of renal diseases—enabling low-dose, durable efficacy for both rare monogenic and common non-monogenic conditions like IgA Nephropathy (IgAN).[1][2][4] Serving patients with chronic kidney diseases affecting over 788 million globally, Purespring solves the lack of transformative options beyond dialysis or transplants by aiming to halt, reverse, or cure disease progression.[2][4] With ~48 employees, a Series B raise of £80m/$105m, and lead program PS-002 advancing for IgAN (global prevalence ~2.5 per 100,000), the company shows strong growth momentum toward clinic.[3][4]
Purespring Therapeutics was founded in 2020 in London, emerging from the seminal research of Professor Moin Saleem, Professor of Paediatric Renal Medicine at the University of Bristol and head of Bristol Renal, a world-leading group on glomerular diseases.[1][3][5] Co-founded with Professor Mauro Giacca, a gene therapy expert in cardiovascular disorders, the company originated from Saleem's breakthrough in treating kidney disease models by targeting podocytes—the first such success globally.[1][3][4] Early traction came via Syncona, which holds 46.3% ownership and seeded the venture as one of the first AAV gene therapy firms focused on kidneys; pivotal moments include developing the FunSel in-vivo screening platform for protective factors across diseases and rapid pipeline buildout.[3] Incorporated as PURESPRING THERAPEUTICS LIMITED (company number 12543677) on April 1, 2020, initially under the name SYNCONA COLLABORATION (S) LIMITED, it has evolved under CEO Haseeb Ahmad (now Julian Hanak) into a ~48-person team blending podocyte biology and gene therapy expertise.[3][4][6]
Purespring rides the gene therapy revolution in underserved organs, targeting kidneys amid a crisis where disease affects 788M+ people, causes 3M annual deaths by 2040, and ranks top-10 globally—yet lacks innovation beyond dialysis/transplants.[2][4] Timing aligns with AAV maturation, podocyte biology advances, and investor focus on precision medicine; market forces like rising CKD prevalence (e.g., IgAN as most common glomerulonephritis) and Series B momentum (£80m from Syncona-led round) favor scalable platforms like GlomThera over systemic approaches.[2][3][4] It influences biotech by proving kidney-specific delivery viability, potentially expanding gene therapy to non-liver organs and accelerating therapies for glomerular diseases via FunSel screening.[1][3]
Purespring is poised to deliver first-in-class kidney gene therapies, with PS-002 entering clinic using Series B funds to target IgAN and beyond, potentially transforming trajectories for millions facing end-stage options.[4] Trends like low-dose AAV refinement, monogenic-to-polygenic expansion, and nephrology investment will propel it; influence may grow via partnerships, pipeline milestones, and FunSel discoveries, positioning as a nephrology leader if podocyte efficacy scales in humans.[2][3][4] As a Syncona-backed pioneer changing kidney disease courses, Purespring exemplifies precision biotech's potential to cure what was once untreatable.[1][3]
Purespring Therapeutics has raised $170.0M across 2 funding rounds. Most recently, it raised $110.0M Series B in October 2024.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Oct 1, 2024 | $110.0M Series B | Therese Liechtenstein, Soffinova Partners | |
| Nov 1, 2020 | $60.0M Series A | Advent Life Sciences |