Pulmocide is a technology company.
Pulmocide has raised $144.0M across 2 funding rounds.
Pulmocide has raised $144.0M in total across 2 funding rounds.
Pulmocide has raised $144.0M in total across 2 funding rounds.
Pulmocide's investors include Adjuvant Capital.
Pulmocide is a UK-based biopharmaceutical company developing novel inhaled therapies for serious respiratory diseases, particularly those caused by fungal infections like *Aspergillus*. Its lead product, opelconazole, is in Phase 3 clinical trials for treating invasive pulmonary aspergillosis (IPA) in patients not responding to standard antifungal therapies, targeting a critical unmet need in hard-to-treat pulmonary conditions.[1][2][6] The company serves patients with acute and chronic respiratory infections, such as IPA, aspergilloma, chronic pulmonary aspergillosis (CPA), allergic bronchopulmonary aspergillosis (ABPA), and severe asthma with fungal sensitization (SAFS), addressing limitations of current systemic antifungals like poor lung penetration and toxicity.[1][4][6] Backed by $52 million in Series C extension funding in 2022, Pulmocide shows strong growth momentum through ongoing Phase 3 trials, manufacturing scale-up, and regulatory designations including FDA Fast Track, Orphan Drug, and QIDP, plus EU Orphan Drug status.[1][2]
Founded in 2007 in London, UK, by William Garth Rapeport, John Murray, Kazuhiro Ito, and Peter Strong, Pulmocide emerged from expertise in respiratory drug development to tackle fungal and viral infections in the lungs.[3][4] The idea stemmed from recognizing gaps in treatments for devastating respiratory conditions, leveraging innovative science to create targeted inhaled antifungals like opelconazole, a fungal CYP51A1 inhibitor.[1][4] Early traction included initial investment from F-Prime Capital in 2013, supporting progression from preclinical stages; pivotal moments feature Phase 3 initiation for IPA in 2022 and the $52 million Series C extension led by Pictet Alternative Advisors and Vivo Capital, fueling clinical advancement and commercialization prep.[2][3]
Pulmocide rides the wave of precision respiratory therapies, capitalizing on rising fungal infection burdens from immunocompromised populations (e.g., cancer, transplant patients) amid antifungal resistance trends.[1][2] Timing aligns with post-pandemic emphasis on inhaled antimicrobials for lung-specific delivery, reducing systemic side effects in a market where aspergillosis affects millions annually with high mortality in refractory cases.[6] Favorable forces include biotech funding for orphan diseases and regulatory incentives; Pulmocide influences the ecosystem by advancing inhaled antifungals, potentially setting standards for *Aspergillus*-related conditions and inspiring similar lung-focused biotechs.[3][4]
Pulmocide is poised for Phase 3 topline data readouts and potential NDA filings for opelconazole in refractory IPA, with commercialization likely by 2027-2028 if successful, expanding to prophylaxis and chronic indications.[1][2][6] Trends like antifungal resistance, aging populations, and inhaled tech adoption will propel growth, alongside pipeline maturation (e.g., PC-1244). Its influence could evolve from niche innovator to respiratory fungal therapy leader, delivering targeted relief where systemic options fail—echoing its mission to transform outcomes for underserved pulmonary patients.[1]
Pulmocide has raised $144.0M across 2 funding rounds. Most recently, it raised $52.0M Series C in December 2022.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Dec 1, 2022 | $52.0M Series C | Adjuvant Capital | |
| May 1, 2021 | $92.0M Series C | Adjuvant Capital |