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§ Private Profile · Hochbergerstrasse 60C, 4057 Basel, Switzerland
Polyneuron Pharmaceuticals AG is a company.
Polyneuron Pharmaceuticals AG has raised $41.3M across 4 funding rounds.
Key people at Polyneuron Pharmaceuticals AG.
Polyneuron Pharmaceuticals AG has raised $41.3M in total across 4 funding rounds.
Polyneuron Pharmaceuticals AG develops a novel class of precision immunotherapies for antibody-mediated autoimmune diseases. Their innovative approach selectively targets specific pathological antibodies, aiming to halt disease progression and restore function. This method precisely modulates the immune system, offering effective treatment while minimizing broad immune suppression and its associated side effects.
Established in 2014 as a spin-off from the University of Basel's Department of Pharmaceutical Sciences, Polyneuron was co-founded by Dr. Ruben Herrendorff, CEO, and Dr. Pascal Haenggi. Their insight focused on creating highly specific drug candidates that precisely intervene in severe autoimmune disorders by modulating pathological antibodies, leveraging academic research.
Polyneuron's therapies are for patients with severe autoimmune conditions, particularly those affecting the nervous system, where current treatments are limited. The company’s long-term vision is to create a new therapeutic paradigm for these debilitating diseases. They aim to deliver highly targeted, effective solutions, significantly improving patient outcomes by pioneering a new generation of immunomodulators.
Polyneuron Pharmaceuticals AG has raised $41.3M in total across 4 funding rounds.
Polyneuron Pharmaceuticals AG's investors include Sofinnova Partners, Emil Bujak, New Enterprise Associates, David Mott, Graziano Seghezzi, EVA%20Basel, Z%C3%BCrcher%20Kantonalbank, Venture Kick.
Polyneuron Pharmaceuticals AG is a Swiss biotechnology company developing precision therapies for antibody-mediated autoimmune diseases, particularly those affecting the nervous system.[1][2][3] Its core Antibody-Catch™ platform uses injectable glycopolymers to selectively eliminate pathological autoantibodies while preserving the rest of the immune system, targeting rare conditions like anti-MAG neuropathy and multifocal motor neuropathy with high unmet needs.[1][3][4] The company serves patients with devastating autoimmune disorders of the peripheral nervous system, addressing the lack of effective, safe treatments by offering a novel immunomodulatory approach that could enable breakthrough therapies.[1][2][4]
Founded in 2014 as a spin-off from the University of Basel's Department of Pharmaceutical Sciences, Polyneuron advanced lead candidate PN-1007 through preclinical milestones, including orphan drug designation from the EMA and promising in vivo data published in PNAS, before it reached discontinued status.[1][4][6] Growth included grants from CTI (Innosuisse), BaseLaunch, and EMA scientific advice, with a team expanding to include experts in neuroimmunology and carbohydrate chemistry.[4]
Polyneuron emerged in 2014 from the University of Basel's Department of Pharmaceutical Sciences, where founders identified a gap in treating antibody-mediated autoimmune diseases driven by anti-carbohydrate autoantibodies.[1][3] Co-founders Ruben Herrendorff (CEO) and Pascal Zenobi-Wong (CSO) leveraged their expertise in pharmaceutical sciences—Ruben in chemical synthesis, assay development, and in vivo pharmacology for lead PN-1007, and Pascal in preclinical development and regulatory interactions—both holding advanced degrees from Swiss universities.[1]
Early traction built through a CTI-funded collaboration with the University of Basel (CHF 418,900), patent filing for Antibody-Catch™, and promising animal model data for anti-MAG neuropathy.[4] Pivotal moments included Venture Kick support, BaseLaunch grants (CHF 130,000 total), hiring of Michael Wacker (former GlycoVaxyn CSO) as Chief Business Officer, EMA orphan drug designation for PN-1007, PNAS publication, and initiation of clinical trial-enabling studies by around 2018.[1][4]
Polyneuron rides the wave of precision immunology, where targeted autoantibody depletion addresses failures of broad immunosuppressants in rare neurological autoimmunities—a market underserved amid rising autoimmune disease prevalence.[1][2][3] Timing aligns with advances in glycopolymer design and regulatory support for orphan drugs, amplified by Switzerland's biotech hub status (Basel ecosystem with EMA proximity).[3][4]
Favorable forces include CTI/Innosuisse funding for de-risking, EMA endorsements accelerating paths to clinic, and investor interest in platform technologies amid $212M precedents like GlycoVaxyn's GSK exit.[1][4] Polyneuron influences the ecosystem by validating Antibody-Catch™ for nervous system applications, inspiring spin-offs and contributing talent—e.g., Herrendorff's move to NXI Therapeutics CEO in 2022—while highlighting unmet needs in anti-carbohydrate autoantibody therapies.[2][4]
Post-PN-1007 discontinuation, Polyneuron's platform endures with PN-1018 in preclinical for motor neuron disease and pending candidates like PN-032/PN-056 for transplantation, signaling pivot potential toward expanded autoimmune and transplant indications.[6] Next steps likely involve partnerships or funding to revive clinical pipelines, leveraging EMA history and Basel network amid biotech M&A trends.
Shaping trends—AI-driven epitope mapping, glycobiology advances, and orphan drug incentives—could propel selective therapies, evolving Polyneuron from neuropathy pioneer to broader immunology player. Its spin-off roots underscore biotech resilience, positioning it to deliver on Antibody-Catch™'s promise for patients long underserved by imprecise treatments.[1][6]
Key people at Polyneuron Pharmaceuticals AG.
Polyneuron Pharmaceuticals AG has raised $41.3M across 4 funding rounds. Most recently, it raised $15.4M POLYNEURON - Series A Extension in September 2020.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Sep 16, 2020 | $15.4M Series A Plus | Sofinnova Partners | Emil Bujak, NEW Enterprise Associates | Announced |
| Mar 28, 2019 | $22.6M Series A | David Mott, Graziano Seghezzi | — | Announced |
| May 14, 2018 | $3.1M Seed | EVA%20Basel | Z%C3%BCrcher%20Kantonalbank | Announced |
| Jun 2, 2015 | $140K Venture Round | Venture Kick | — | Announced |