Outpace Bio is a technology company.
Outpace Bio uses AI-powered protein design to create proteins that program engineered cells for improved function inside patients, aiming to revolutionize cell therapy.
Outpace Bio has raised $165.0M across 2 funding rounds.
Outpace Bio has raised $165.0M in total across 2 funding rounds.
Outpace Bio is a biotechnology company developing AI-powered protein design technologies to engineer immune cells for more effective and safer cell therapies targeting solid tumors.[1][2] The company builds programmable T cell products, such as its lead candidate OPB-101, a mesothelin-specific CAR T cell enhanced by proprietary platforms like OUTSMART™, OUTLAST™, OUTSPACER™, and OUTSAFE™, serving patients with advanced cancers like platinum-resistant ovarian cancer.[1][2][3] These therapies address key limitations in current cell treatments—such as immune exhaustion, poor persistence, and toxicity—by enabling cells to make context-aware decisions in the tumor microenvironment, with OPB-101 on track for IND clearance and first dosing in 2025.[1][2] Outpace has raised approximately $200 million in total funding, including a $144 million oversubscribed Series B in August 2024 and a $30 million Series A, fueling pipeline expansion and clinical advancement.[1][4]
Outpace Bio was co-founded by Marc Lajoie (CEO) and Scott Boyken, pioneers in protein design, alongside Stan Riddell from Fred Hutch Cancer Center, emerging from collaborations that advanced Lyell Immunopharma's cell therapy pipeline.[2][4][5] The idea stemmed from recognizing that while cell therapies like KYMRIAH® succeeded in blood cancers since 2017, solid tumors—over 90% of cancers—remained challenging due to immune cells' poor performance in hostile environments; the founders developed proteins to help cells kill tumors selectively.[5] Pivotal early traction came from spinning out of Lyell with support from investors like ARTIS Ventures and Lyell Immunopharma, closing a $30 million Series A to build "next-generation smart cell therapies" using synthetic biology.[4][5] This foundation has driven rapid progress, including the 2024 Series B and partnerships incorporating their tech into broader cell therapy efforts.[1][4]
Outpace stands out in cell therapy through its plug-and-play protein engineering platform, powered by AI to design custom proteins that reprogram cells for superior efficacy and safety across any cell type or manufacturing method.[2][3]
These stackable technologies solve core barriers unmet by traditional approaches, enabling curative potential.[2][4]
Outpace rides the convergence of AI-driven protein design and synthetic biology in cell therapy, targeting solid tumors where legacy CAR-T therapies fail due to exhaustion, poor infiltration, and toxicity.[2][3][5] Timing aligns with post-2017 approvals like KYMRIAH® proving cell therapy's promise in liquid tumors, now extending to solids amid surging investment—evidenced by Outpace's $200 million raise.[1][5] Favorable market forces include advances in AI for de novo protein creation (beyond AlphaFold-style prediction) and demand for "smart" cells that adapt in vivo, reducing reliance on co-therapies.[2][4] Outpace influences the ecosystem via collaborations (e.g., Lyell), platform licensing, and open tools like OpenFold, accelerating industry-wide cures while de-risking development for partners.[4][5]
Outpace is poised for clinical milestones, with OPB-101 entering trials in 2025 and funds expanding a multi-asset pipeline for solid tumors.[1] Trends like AI-optimized synbio and combination therapies will amplify their platform, potentially enabling off-the-shelf cells and autoimmune applications.[2][4] Their influence may grow through more partnerships and tech adoption, solidifying Outpace as a key enabler of curative cell therapies that "outsmart" cancer's complexity—building directly on their mission to program cells for right decisions in the toughest contexts.[2][5]
Outpace Bio has raised $165.0M in total across 2 funding rounds.
Outpace Bio's investors include aMoon Fund, GSR Ventures, IA Capital Group, Playground Global, RA Capital, Webb Investment Network.
Outpace Bio has raised $165.0M across 2 funding rounds. Most recently, it raised $140.0M Series B in July 2024.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Jul 1, 2024 | $140.0M Series B | aMoon Fund, GSR Ventures, IA Capital Group, Playground Global, RA Capital, Webb Investment Network | |
| Mar 1, 2023 | $25.0M Series A | GSR Ventures, IA Capital Group, Playground Global, Webb Investment Network |