OncoResponse

OncoResponse is a technology company.

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Updated: Feb 17, 2026 ·

Recent News & Mentions

May 1, 2023FundingOncoResponse - Series D Mar 1, 2021FundingOncoResponse - Series C Sep 1, 2018FundingOncoResponse - Series B May 1, 2016FundingOncoResponse - Series A

Financial History

OncoResponse has raised $108.0M across 4 funding rounds. Most recently, it raised $14.0M Series D in May 2023.

Total Raised

$108.0M

Valuation

N/A

Funding Rounds Raised

Date	Round	Other Investors
May 1, 2023	$14.0M Series D	125 Ventures, Canaan Partners, Codon Capital, Commerce Ventures, Digitalis Ventures, GE Ventures, RiverVest, Roche Venture Fund, Thompson Hutton (Thompson Hutton)
Mar 1, 2021	$41.0M Series C	125 Ventures, Canaan Partners, Commerce Ventures, GE Ventures, Thompson Hutton (Thompson Hutton)
Sep 1, 2018	$40.0M Series B	125 Ventures, Canaan Partners, Commerce Ventures, GE Ventures, Thompson Hutton (Thompson Hutton)
May 1, 2016	$13.0M Series A	125 Ventures, Canaan Partners, Commerce Ventures, GE Ventures, Thompson Hutton (Thompson Hutton)

Financial History

OncoResponse has raised $108.0M across 4 funding rounds.

Total Raised

$108.0M

Valuation

N/A

Deep Dive

High-Level Overview

OncoResponse is a clinical-stage immuno-oncology biotech company developing cancer immunotherapies by analyzing the immune systems of patients who exhibit elite responses to treatments like checkpoint inhibition.[1][2] It builds novel antibodies targeting the tumor microenvironment, with its lead candidate OR502, an anti-LILRB2 monoclonal antibody, advancing in Phase 1/2 trials for advanced solid tumors including cutaneous melanoma and NSCLC, where it showed partial responses and a 65% disease control rate in dose escalation.[1][3] The company serves cancer patients with hard-to-treat tumors, solving the problem of immune suppression in the tumor microenvironment by mining human memory B-cells from elite responders via a proprietary discovery platform, in alliance with MD Anderson Cancer Center.[2][3] Growth momentum includes CPRIT grant funding, manufacturing partnerships like Just-Evotec Biologics for OR502's Phase 1 supply, and dosing the first patient in November 2023 trials.[1][3]

Origin Story

OncoResponse emerged in 2020 from a strategic alliance between MD Anderson Cancer Center and Theraclone Sciences, leveraging Theraclone's I-STAR immune repertoire screening technology to identify therapeutic antibodies from elite cancer responders.[5] This partnership provided access to blinded patient tissues, clinical data, and MD Anderson's oncology expertise, accelerating discovery of antibodies modulating myeloid cells in tumors.[2] Key early traction came from deploying the proprietary B-cell platform to screen thousands of human antibodies, leading to OR502's development and entry into clinical studies funded by CPRIT.[1][3] Based in Seattle, WA, the company has built momentum through alliances with investors like ARCH Ventures, Canaan, and Takeda Ventures.[1]

Core Differentiators

Proprietary B-Cell Discovery Platform: Mines memory B-cells from elite immunotherapy responders to rapidly identify immunomodulatory antibodies against high-value tumor microenvironment targets, unlike traditional methods.[1][2]
MD Anderson Collaboration: Provides unique access to patient samples, genotypic/clinical data, and translational expertise, enabling validation of antibodies in real-world elite responses.[2][5]
Lead Asset OR502: Blocks LILRB2 to unleash immune attack on tumors; Phase 1 data showed PRs and 65% disease control in melanoma/NSCLC, with ongoing efficacy trials solo and with anti-PD-1.[1][3]
Manufacturing and Funding Edge: Partnered with Just-Evotec for scalable Phase 1 production using high-expression CHO-K1 systems; backed by CPRIT grants and top VCs like Rivervest and Oxford Finance.[1][3]

Role in the Broader Tech Landscape

OncoResponse rides the immuno-oncology wave, capitalizing on checkpoint inhibitors' success by addressing resistance through tumor microenvironment modulation—a key trend as ~70% of patients don't respond to PD-1 therapies.[2][3] Timing aligns with maturing antibody engineering and elite responder insights, amplified by MD Anderson's tissue biorepositories amid rising demand for myeloid-targeted agents.[2][5] Market forces like CPRIT funding and biotech manufacturing advances (e.g., continuous bioprocessing) favor rapid clinical progression.[1][3] It influences the ecosystem by validating human-derived antibodies from real patients, potentially setting a blueprint for precision immuno-oncology and inspiring similar platforms in solid tumor therapies.[1][2]

Quick Take & Future Outlook

OncoResponse's platform positions it for pipeline expansion beyond OR502, with next milestones in Phase 1/2 readouts for melanoma/NSCLC and potential combo regimens.[1][3] Trends like AI-enhanced antibody discovery and myeloid checkpoint inhibitors will shape its path, especially as tumors evolve resistance to T-cell therapies. Its influence may grow through MD Anderson alliances and VC backing, evolving into a multi-asset player in tumor microenvironment modulation—turning elite responder clues into broadly accessible cancer breakthroughs, much like how patient insights birthed today's immunotherapy standards.[2][5]

Sources

Frequently Asked Questions

How much funding has OncoResponse raised?

OncoResponse has raised $108.0M in total across 4 funding rounds.

Who are OncoResponse's investors?

OncoResponse's investors include 125 Ventures, Canaan Partners, Codon Capital, Commerce Ventures, Digitalis Ventures, GE Ventures, RiverVest, Roche Venture Fund, Thompson Hutton (Thompson Hutton).