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§ Private Profile · Cambridge, United Kingdom
Microbiotica is a technology company.
Microbiotica is a leading, clinical stage biopharmaceutical company specialising in the development of precision live biotherapeutic products (LBPs) with lead products in immuno-oncology and inflammatory bowel disease.
Microbiotica has raised $73.0M across 2 funding rounds.
Microbiotica has raised $73.0M in total across 2 funding rounds.
Microbiotica has raised $73.0M in total across 2 funding rounds.
Microbiotica's investors include Carl-Johan Spak, Tencent, ARCH Venture Partners, Cambridge Innovation Capital, HealthCap, Mubadala, Judith Hartley MBE, Seventure Partners.
Microbiotica has raised $73.0M across 2 funding rounds. Most recently, it raised $68.0M Series B in February 2022.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Feb 1, 2022 | $68M Series B | Carl Johan Spak, Tencent Holdings | ARCH Venture Partners, Cambridge Innovation Capital, HealthCap, Mubadala, Judith Hartley MBE, Seventure Partners | Announced |
| Oct 1, 2018 | $5M Series U | — | Seventure Partners | Announced |
Microbiotica is a clinical-stage biopharmaceutical company developing precision live biotherapeutic products (LBPs)—orally delivered consortia of highly defined bacterial strains—for immuno-oncology and inflammatory bowel disease (IBD).[1][4] Its lead candidates include MB097, a co-therapy to enhance immune checkpoint inhibitors like KEYTRUDA in advanced melanoma patients (in Phase 1b MELODY-1 trial), and a program for ulcerative colitis (UC).[1][2] The company serves patients with hard-to-treat cancers and IBD, addressing unmet needs by modulating the gut microbiome to improve therapy responses and disease outcomes, powered by a clinic-led discovery platform that identifies bacteria linked to clinical benefits.[1][3] With £62M raised (including a £50M Series B in 2022), Microbiotica operates from Cambridge, UK, showing strong growth via advancing two Phase 1b programs and partnerships like Genentech.[1][2]
Founded in 2016 as a spin-out from the Wellcome Sanger Institute in Cambridge, UK, Microbiotica translates pioneering microbiome research into therapeutics.[2][7] Key figure Trevor Lawley, chief scientific officer, led the Sanger team that overcame barriers in isolating gut bacteria and building a reference genome database after a decade of investment.[6] The idea emerged from clinical observations linking gut microbiomes to immunotherapy responses in cancer and IBD outcomes, with early traction from collaborations (e.g., Cancer Research UK, Cambridge University) and scaling into a validated platform.[2][5] Pivotal moments include the 2022 £50M financing to fund Phase 1b trials and expansion of its culture collection and bioinformatics tools.[1][2]
Microbiotica rides the microbiome therapeutics wave, fueled by discoveries that gut bacteria influence immunotherapy efficacy (e.g., ICIs in cancer) and IBD pathology, revolutionizing precision medicine.[2][6] Timing is ideal post-2022 funding and Phase 1b progress, amid rising interest in host-microbe interactions for "multi-therapeutic" applications like biomarkers and companion diagnostics.[2][4] Market forces favoring it include FDA approvals of similar LBPs (e.g., Vowst for rCDI), limited manufacturing capacity creating barriers for others, and demand for side-effect-free alternatives addressing disease roots.[6][9] It influences the ecosystem by licensing tech for new indications, advancing gut epithelial repair, and setting standards in culturing/isolation, potentially expanding to infections, autoimmunity, and neurology.[5][7]
Microbiotica's Phase 1b data from MELODY-1 (expected ~2023-2024) and UC trials could validate its platform, unlocking partnerships and follow-on funding for pipeline expansion into new diseases.[2] Trends like AI-driven microbiome analysis and combo therapies with ICIs will accelerate growth, though manufacturing scale-up via CMOs remains key.[6] Its influence may evolve from pioneer to category leader, delivering first-in-class LBPs that transform oncology and IBD treatment—building on its clinic-first foundation to make microbiome magic mainstream.[8]