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§ Venture Capital · San Francisco, CA, USA
family office investing in growth and pre-IPO stage startups with established ARR, focused on automation and scalable platforms.
Key people at Knockout Capital.
Knockout Capital is a Los Angeles, California-based family office specializing in investments within the automation and scalable platforms sectors. The firm actively seeks companies demonstrating established Annual Recurring Revenue (ARR) and aims to back over 100 startups annually, often through direct co-investment or crowdfunding initiatives. Knockout Capital primarily focuses on growth and pre-IPO stage companies, deploying individual check sizes ranging from $2 million to $10 million per transaction. Its investment strategy is funded exclusively via family office resources, targeting promising ventures in both the USA and Japan. General Partner and Managing Director Sarah K. Osone, along with team member Ayaz Khan, are among the key personnel overseeing the firm's investment activities and portfolio. Its business model centers on family office investing in growth and pre-IPO stages with check sizes from $2M to $10M, funded via family office resources.
Knockout Capital is a venture capital and consumer strategist fund founded in 2019, with a mission to invest in startups and companies that leverage automation, scalable platforms, and data-driven research. The firm operates across both private and public markets, focusing on sectors such as biopharmaceuticals, medical technology, robotics, artificial intelligence, and health care. Its investment philosophy centers on backing companies with established annual recurring revenue (ARR), often through crowdfunding or co-investment syndicates, and prioritizing businesses that are 2–3 years old.
Knockout Capital has made a notable impact on the startup ecosystem by supporting early-growth companies in the U.S. and select international markets, with a particular emphasis on innovation in health tech and automation. Its portfolio includes startups like Nucleus Health, Sawacare, and Virion Biotherapeutics, reflecting its commitment to advancing technologies that solve real-world health and operational challenges.
Knockout Capital was founded in 2019 by Kiyoko Osone, a seasoned investor with a background in biopharmaceuticals and health technology. The firm began as a specialized venture capital vehicle focused on medical and robotics startups, but quickly expanded its mandate to include broader automation and platform-driven businesses. Over time, Knockout Capital evolved into a family office and consumer strategist fund, leveraging research from top academic and industry institutions to guide its investment decisions. The firm’s early years were marked by a steady pace of deal-making, with a peak in activity around 2021, and a growing network of co-investors and strategic partners.
Knockout Capital is riding the wave of digital transformation in health care and automation, two sectors experiencing rapid growth due to advances in AI, robotics, and data analytics. The firm’s focus on established ARR and scalable platforms aligns with the increasing demand for proven, revenue-generating startups in a market wary of speculative ventures. By bridging private and public markets and leveraging institutional research, Knockout Capital is helping to shape the next generation of health tech and automation leaders. Its presence in the U.S. and select international markets positions it as a key player in the global innovation ecosystem.
Knockout Capital is poised to continue its growth trajectory by doubling down on its core strengths: sector expertise, strategic partnerships, and a data-driven investment approach. As automation and health tech become even more central to the global economy, the firm’s ability to identify and back scalable, revenue-generating startups will likely amplify its influence. Future trends such as AI-driven diagnostics, robotic process automation, and decentralized health platforms are likely to shape its investment pipeline. Knockout Capital’s evolution from a niche VC to a multifaceted consumer strategist fund reflects its adaptability and long-term vision, making it a noteworthy player in the venture capital landscape.
Key people at Knockout Capital.
