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§ Private Profile · Boston, MA, USA
Biopharmaceutical company developing novel therapies for psychiatric and neurological disorders, focused on schizophrenia treatment.
Karuna Therapeutics has raised $130.0M across 4 funding rounds.
Key people at Karuna Therapeutics.
Karuna Therapeutics has raised $130.0M in total across 4 funding rounds.
Karuna Therapeutics develops novel therapies for psychiatric and neurological disorders, primarily focusing on schizophrenia and related conditions through a new mechanism of action, and is based in Boston, Massachusetts. The biopharmaceutical company's lead product, Cobenfy™ (KarXT), combines xanomeline and trospium to target muscarinic receptors, aiming to treat schizophrenia with reduced side effects, and received FDA approval in September 2024. Karuna Therapeutics scaled significantly, growing from a single employee to over 350, and raised approximately $2 billion in funding through private investments and a 2019 IPO before its acquisition. In March 2024, Bristol Myers Squibb completed its acquisition of Karuna for $14 billion, integrating its promising neuroscience pipeline. Key figures associated with the company include CEO Bill Meury and co-founders Andrew Miller, Eric Elenko, and Peter Jeffrey Conn. The organization was founded in 2009 by Andrew Miller and others.
Key people at Karuna Therapeutics.
Karuna Therapeutics has raised $130.0M across 4 funding rounds. Most recently, it raised $12.0M Series B Extension in April 2019.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Apr 1, 2019 | $12M Series B Plus | — | Alexandria Venture Investments, Robert Nelsen, Eventide Asset Management, Fidelity Management & Research Company, Partner Fund Management, Heather Preston, PureTech Health, Sands Capital, James Healy | Announced |
| Mar 1, 2019 | $68M Series B | — | Amino Capital, ARCH Venture Partners, Dolby Family Ventures, ED Mathers, Sofinnova Investments, SR ONE, Bill Gates, SUE XU | Announced |
| Aug 1, 2018 | $42M Series A | — | Amino Capital, ARCH Venture Partners, Third Rock Ventures, Bill Gates, SUE XU, Steven Paul, PureTech Health | Announced |
| Jun 19, 2018 | $8M Venture Round | — | — | Announced |
Karuna Therapeutics has raised $130.0M in total across 4 funding rounds.
Karuna Therapeutics's investors include Alexandria Venture Investments, Robert Nelsen, Eventide Asset Management, Fidelity Management & Research Company, Partner Fund Management, Heather Preston, PureTech Health, Sands Capital, James Healy, Amino Capital, ARCH Venture Partners, Dolby Family Ventures.
Karuna Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel therapies for central nervous system (CNS) disorders, particularly psychiatric and neurological conditions such as schizophrenia and dementia-related psychosis. Its lead product candidate, KarXT, targets muscarinic receptors in the brain to reduce psychotic symptoms and improve cognition, aiming to offer a more holistic and better-tolerated treatment option than existing therapies. The company serves patients with severe neuropsychiatric disorders, addressing the significant unmet need for effective and safer treatments, and has demonstrated promising clinical results that support its growth momentum and pipeline expansion[1][2][3].
Founded by experts in neuroscience and drug development, Karuna emerged from research into muscarinic receptor agonists originally intended for Alzheimer's disease memory impairment, which serendipitously showed efficacy in reducing psychosis symptoms. The company innovated by combining xanomeline with trospium to block side effects that had previously halted development, enabling advancement into clinical trials. This breakthrough and subsequent collaborations, such as with PsychoGenics for drug discovery, have been pivotal in establishing Karuna’s position in CNS drug development[1][3][7].
Karuna is riding the trend of precision neuroscience therapeutics, addressing the complexity of CNS disorders with targeted receptor modulation rather than broad-spectrum antipsychotics. The timing is critical as the global burden of neuropsychiatric diseases grows and existing treatments often have limited efficacy and significant side effects. Advances in molecular biology, receptor pharmacology, and computational drug discovery create favorable market forces for Karuna’s approach. By advancing first-in-class therapies, Karuna influences the broader ecosystem by setting new standards for safety and efficacy in psychiatric treatment and inspiring innovation in CNS drug development[1][2][3].
Now a wholly owned subsidiary of Bristol Myers Squibb as of 2024, Karuna is positioned to accelerate the commercialization of KarXT, with a Prescription Drug User Fee Act (PDUFA) date set for September 26, 2024, for schizophrenia treatment. Future trends shaping their journey include expanding indications (e.g., Alzheimer’s psychosis, Bipolar I disorder), leveraging machine learning for drug discovery, and integrating into a larger biopharma infrastructure to scale impact. Karuna’s influence is likely to grow as it helps redefine treatment paradigms for CNS disorders, potentially transforming patient outcomes and setting a precedent for innovative neuroscience therapeutics[8].