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InflaRx is a technology company.
InflaRx has raised $89.2M across 2 funding rounds.
InflaRx has raised $89.2M in total across 2 funding rounds.
InflaRx is a biopharmaceutical company focused on applying its proprietary anti-C5a and C5aR inhibitors to the treatment of life-threatening or debilitating inflammatory diseases with high unmet medical need.
InflaRx has raised $89.2M in total across 2 funding rounds.
InflaRx's investors include Bain Capital Life Sciences, Cormorant Asset Management, RA Capital Management, bm|t, KfW, Staidson Hongkong Investment Company.
InflaRx N.V. (Nasdaq: IFRX) is a biopharmaceutical company developing anti-inflammatory therapeutics targeting the complement system's C5a/C5aR signaling pathway to treat acute, life-threatening, and chronic inflammatory diseases.[1][2][5] Its lead product, vilobelimab (GOHIBIC), is an intravenous anti-C5a monoclonal antibody with U.S. FDA Emergency Use Authorization for COVID-19 in critically ill patients on mechanical ventilation or ECMO, showing disease-modifying activity in trials for infections, pyoderma gangrenosum, and other indications; the company also advances INF904, an oral C5aR inhibitor with positive Phase 2a data in hidradenitis suppurativa (HS) and chronic spontaneous urticaria (CSU).[1][2][4] InflaRx serves patients with severe inflammatory conditions, addressing unmet needs in uncontrolled complement activation that drives tissue damage in diseases like COVID-19 complications, HS, and CSU, with recent momentum from topline Phase 2a results (November 2025) and ongoing Phase 3 analyses for vilobelimab.[1]
InflaRx GmbH was founded in December 2007 in Jena, Germany, a hub for acute care clinical trials, building on breakthroughs in monoclonal anti-C5a antibodies that selectively block C5a without disrupting the membrane attack complex.[1][2][4] In 2008, the company achieved a key discovery enabling highly potent, selective anti-C5a antibodies, leading to global patents; by 2011, it launched a Phase I trial for vilobelimab, confirming safety and tolerability.[4] Pivotal early traction came in 2015 with a Phase IIa trial validating vilobelimab in life-threatening infections with organ dysfunction, followed by COVID-19 studies showing 23.9% relative reduction in 28-day mortality in Phase III (PANAMO trial).[4] The company expanded with INF904 for chronic indications, dosing the first patient in a Phase IIa basket study, and established subsidiaries in Munich, Germany, and Ann Arbor, MI, USA.[2][4][5]
InflaRx rides the wave of precision immunology, targeting complement dysregulation—a key driver in inflammatory diseases amid rising chronic conditions like HS, CSU, and post-viral syndromes.[1][2] Timing aligns with post-COVID insights into complement's role in hyperinflammation, boosting vilobelimab's EUA and validating C5a blockade; market forces favor it as biologics shift toward selective inhibitors over broad immunosuppressants, with oral candidates like INF904 tapping demand for convenient chronic therapies.[1][4][5] It influences biotech by pioneering C5a-specific tools, potentially expanding complement modulation beyond rare diseases into high-prevalence inflammation, fostering ecosystem investment from firms like Bain Capital Life Sciences.[2]
InflaRx's momentum hinges on vilobelimab Phase 3 readouts (e.g., pyoderma gangrenosum, December 2025 update) and INF904 advancement, potentially unlocking commercialization and partnerships in inflammation.[1][4] Trends like oral complement inhibitors and AI-driven trial design will shape its path, with expanded indications (e.g., HS/CSU) driving growth amid a $20B+ anti-inflammatory market. Its influence may evolve from COVID responder to chronic disease leader, amplifying biotech's focus on complement precision—positioning InflaRx as a targeted innovator in an era of tailored therapies.[1][2]
InflaRx has raised $89.2M across 2 funding rounds. Most recently, it raised $55.0M Series D in October 2017.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Oct 1, 2017 | $55.0M Series D | Bain Capital Life Sciences, Cormorant Asset Management, RA Capital Management | |
| Jul 21, 2016 | $34.1M Series C | bm|t, KfW, Staidson Hongkong Investment Company |