Graphite Bio is a technology company.
Graphite Bio has raised $195.0M across 2 funding rounds.
Graphite Bio has raised $195.0M in total across 2 funding rounds.
Graphite Bio, Inc. (NASDAQ: GRPH) was a clinical-stage biotechnology company developing gene editing therapies to treat serious genetic disorders, primarily using its proprietary Graphite Platform based on CRISPR-Cas9 technology for precise DNA modifications in hematopoietic stem cells.[1][2][3] The company targeted conditions like sickle cell disease (lead program GPH101/GRPH-001), beta-thalassemia (GRPH-002), X-linked severe combined immunodeficiency (XSCID), alpha-1 antitrypsin deficiency, and Gaucher disease, aiming for "one dose, one cure" outcomes with high-efficiency targeted gene integration to replace defective genes.[1][2][3][4][7] It served patients with single-gene disorders, addressing unmet needs in genetic diseases affecting millions, such as sickle cell disease impacting 6.5 million worldwide, through therapies designed to minimize side effects compared to earlier gene editing approaches.[2]
Graphite initiated its first Phase 1/2 trial for sickle cell disease in 2022, enrolling about 30 patients at sites including Stanford and the University of Alabama, with early data expected in 2023.[1][2] However, by February 2023, it discontinued its lead program, cut its workforce by half, and pursued strategic alternatives, culminating in a reverse merger with Lenz Therapeutics—a presbyopia eye drop developer—in 2023, after which Graphite was renamed LENZ Therapeutics, shifted focus to vision treatments, and relocated headquarters to San Diego.[6]
Founded in 2020 in South San Francisco, California, Graphite Bio emerged from academic research by Matthew Porteus, a Stanford pediatric hematologist who spent four years refining CRISPR-based techniques for targeted DNA integration to correct the sickle cell mutation in hematopoietic stem cells.[4][5] The company launched with $45 million in Series A financing led by investors like Versant Ventures, quickly advancing Porteus's work toward clinical trials planned for early 2021.[4] CEO Josh Lehrer, formerly chief medical officer at Global Blood Therapeutics, joined to lead development of the Graphite Platform, emphasizing precise gene correction over less accurate methods.[2][4]
Early traction included preclinical programs for multiple genetic diseases and rapid progression to the Phase 1/2 sickle cell trial in 2022 (GPH101), building on CRISPR-Cas9 for genomic engineering.[1][3] Pivotal moments were the 2020 launch amid CRISPR hype and partnerships to enhance capabilities, though challenges like manufacturing hurdles emerged.[2]
Graphite Bio stood out in the crowded gene editing field through these key strengths:
Graphite rode the CRISPR gene editing wave, a transformative trend in biotech since the mid-2010s, targeting incurable genetic diseases like sickle cell amid growing regulatory support and investor interest in "one-time cures."[2][3][4] Timing was ideal post-2020 CRISPR Nobel recognition, with market forces favoring precise, side-effect-minimizing therapies for a 6.5 million-patient sickle cell market and similar orphan indications.[2] It influenced the ecosystem by advancing targeted integration techniques from academia to clinic, competing with leaders like CRISPR Therapeutics and fostering partnerships, though manufacturing challenges highlighted industry hurdles.[2][4]
The company's pivot via the 2023 Lenz merger reflected broader biotech dynamics: strategic realignments amid clinical setbacks, redirecting public biotech resources (e.g., $53.5M PIPE financing) to high-potential areas like presbyopia—a $3B+ U.S. market—demonstrating adaptability in volatile funding environments.[6]
Graphite Bio's gene editing ambitions peaked with its 2022 sickle cell trial launch but ended with the 2023 discontinuation and reverse merger into LENZ Therapeutics, now focused on presbyopia eye drops under new leadership like CEO Eef Schimmelpennink.[6] As LENZ, it targets Phase 3 milestones for a once-daily drop addressing 128 million U.S. patients, leveraging Graphite's public infrastructure for near-term value inflection.[6]
Trends like AI-augmented gene editing and ophthalmology demand will shape LENZ's path, potentially evolving its influence from genetic cures to accessible vision therapies amid biotech consolidation. This pivot underscores how clinical-stage biotechs maximize value through reinvention, tying back to Graphite's original mission of innovative treatments for unmet needs—now rechanneled to everyday vision challenges.[6]
Graphite Bio has raised $195.0M in total across 2 funding rounds.
Graphite Bio's investors include AMR Action Fund, Frazier Healthcare Partners, General Atlantic, RA Capital, Samsara BioCapital, Versant Ventures.
Graphite Bio has raised $195.0M across 2 funding rounds. Most recently, it raised $150.0M Series B in March 2021.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Mar 1, 2021 | $150.0M Series B | AMR Action Fund, Frazier Healthcare Partners, General Atlantic, RA Capital, Samsara BioCapital, Versant Ventures | |
| Sep 1, 2020 | $45.0M Series A | AMR Action Fund, Frazier Healthcare Partners, General Atlantic, Samsara BioCapital, Versant Ventures |