Faeth Therapeutics is a technology company.
Faeth Therapeutics has raised $92.0M across 3 funding rounds.
Faeth Therapeutics has raised $92.0M in total across 3 funding rounds.
Faeth Therapeutics has raised $92.0M in total across 3 funding rounds.
Faeth Therapeutics's investors include F-Prime Capital Partners, Future Ventures, General Catalyst, Khosla Ventures, Matthew McAviney, OrbiMed.
Faeth Therapeutics is a clinical-stage biotechnology company developing nutrition-based therapies and metabolic interventions to treat cancer by targeting tumor metabolism.[2][3] It builds a platform combining dietary modifications, such as nonessential amino acid restriction, with drugs like PI3K and mTOR inhibitors to suppress cancer growth while sparing healthy cells, serving cancer patients in ongoing clinical trials like PIKTOR for endometrial cancer, which showed an 80% response rate.[1][3][4][5] The company solves the problem of cancer resistance to traditional single-target therapies by using AI-driven, multi-nodal approaches to disrupt interconnected metabolic pathways fueling tumor proliferation.[3][5] With $92 million in total funding, including a $25 million round in October 2025 to advance Phase 2 trials, Faeth demonstrates strong growth momentum backed by top investors.[4]
Faeth Therapeutics was founded in 2019 in San Francisco by a team of renowned oncologists and cancer biologists from institutions like Cornell, Columbia, Cambridge, Crick Institute, and Sloan Kettering, including Lewis Cantley—a potential Nobel contender—along with Scott Lowe, Siddhartha Mukherjee, Greg Hannon, and Karen Vousden.[1][4][5] The idea emerged from over a decade of research showing cancers' unique metabolic vulnerabilities, such as sensitivity to nutritional changes like amino acid starvation, published in journals like *Nature* and *Science*, enabling tumor suppression with minimal impact on normal cells.[1] CEO and cofounder Anand Parikh, a corporate lawyer with prior roles at Virta Health (a nutrition-based therapeutics firm), joined to lead operations, bringing business expertise to the scientific vision.[1] Early traction included in-licensing drugs like serabelisib (FTH-001) and sapanisertib (FTH-003) for the PIKTOR regimen, now in clinical trials with patient support via the Faeth app.[3][4][5]
Faeth rides the cancer metabolism wave, a post-2018 trend leveraging 50% of the druggable genome's metabolic genes, following immuno-oncology's rise in the 2010s.[3] Timing aligns with advances in AI for biology and precision nutrition, addressing traditional therapies' (surgery, radiation, chemo) limitations by rethinking cancer as a metabolic disease.[1][3][5] Market forces like rising cancer incidence, drug resistance, and demand for combinatorial regimens favor Faeth, especially in hormone-sensitive cancers like endometrial and breast where PI3K/AKT/mTOR mutations dominate.[5] It influences the ecosystem by pioneering "metabolism as the next pillar" of oncology, inspiring food-as-medicine models and attracting biotech investment into nutrient-drug synergies.[1][4]
Faeth is poised to advance PIKTOR into broader Phase 2/3 trials across metabolic-driven cancers, potentially defining a new treatment category with its nutrition-drug platform.[4][5] Trends like AI-accelerated drug discovery and personalized metabolic therapies will accelerate its pipeline, while expanded access policies and app-based support could drive adoption.[3] Its influence may evolve from niche innovator to ecosystem shaper, licensing tech or partnering with big pharma amid a $92 million war chest fueling category leadership—transforming cancer care from incremental to metabolic mastery.[1][4]
Faeth Therapeutics has raised $92.0M across 3 funding rounds. Most recently, it raised $25.0M Series A in October 2025.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Oct 1, 2025 | $25.0M Series A | F-Prime Capital Partners, Future Ventures, General Catalyst, Khosla Ventures, Matthew McAviney, OrbiMed | |
| Jun 1, 2022 | $47.0M Series A | F-Prime Capital Partners, Future Ventures, General Catalyst, Khosla Ventures, Matthew McAviney, OrbiMed | |
| Jan 1, 2022 | $20.0M Seed | F-Prime Capital Partners, Future Ventures, General Catalyst, Khosla Ventures, Matthew McAviney, OrbiMed |