EnClear Therapies is a technology company.
EnClear Therapies has raised $12.0M across 2 funding rounds.
EnClear Therapies has raised $12.0M in total across 2 funding rounds.
EnClear Therapies is a Cambridge, USA-based neurotechnology company developing the EnTrega CSF Management Platform, a device-based system that precisely controls cerebrospinal fluid (CSF) flow to overcome the blood-brain barrier (BBB) for enhanced drug delivery in central nervous system (CNS) diseases.[1][2][4][5] It serves patients with neurodegenerative diseases, neuro-oncology conditions like Leptomeningeal Carcinomatosis and brain tumors, and potentially lysosomal storage and autoimmune disorders, solving the critical challenge of ineffective CNS drug penetration by enabling controlled, continuous, personalized therapeutic delivery, monitoring, and sampling.[1][4][5] The company shows strong growth momentum through NIH SBIR grants (e.g., Phase I/II for preclinical testing in glioma models), venture funding from syndicates including 20/20 HCP, Thiel Capital, and Quark Venture, board additions of industry experts, and plans for first-in-human trials in Amyotrophic Lateral Sclerosis (ALS).[1][2][4][6]
EnClear Therapies was co-founded by Anthony DePasqua (CEO), who leads with a focus on revolutionizing CNS treatment via CSF manipulation.[2][4] The idea emerged from addressing the BBB's limitations in drug delivery, leading to a platform that uses lumbar and cerebral ventricle access points, precision pumps, sensor arrays, and flow reversal for targeted therapies like gene therapies (e.g., anti-sense oligonucleotides for Frontal Temporal Dementia) and chemotherapy (e.g., Topotecan in minipig glioma models).[1][5] Early traction includes NIH-funded SBIR projects for preclinical development, partnerships like with QurAlis for brain drug delivery, and recent funding to advance neuro-oncology programs, culminating in board expansions with experts from 20/20 HCP, Thiel Capital, and Quark Venture.[1][2][4][6]
EnClear rides the converging trends of neurotechnology, precision medicine, and CNS therapeutics, where BBB challenges limit ~98% of drugs from reaching the brain, amid rising neurodegenerative and oncology burdens.[1][2] Timing aligns with advances in gene therapies, ASOs, and AI-enhanced devices, amplified by market forces like NIH funding for SBIR innovations and investor interest in transformative medtech (e.g., from Thiel Capital, brain tumor funds).[1][2][4] It influences the ecosystem by enabling partnerships across bio/pharma/medtech, accelerating therapies like QurAlis' candidates, and addressing unmet needs in neuro-oncology via improved CSF management.[4][5][6]
EnClear is poised for first-in-human ALS trials and neuro-oncology preclinical expansion, leveraging funding to scale the EnTrega platform into neurodegenerative and autoimmune applications through partnerships.[2][4][5] Trends like AI-driven personalization and combo therapies with next-gen drugs will shape its path, potentially evolving its influence from niche innovator to CNS delivery standard-setter. This positions EnClear to extend lives in high-unmet CNS spaces, fulfilling its mission from BBB breakthrough to clinical impact.[1][2][5]
EnClear Therapies has raised $12.0M in total across 2 funding rounds.
EnClear Therapies's investors include Acton Capital Partners, Founders Fund, Presight Capital, Rethink Ventures, Thiel Capital, Valar Ventures, Calm/Storm Ventures, Tom Williams.
EnClear Therapies has raised $12.0M across 2 funding rounds. Most recently, it raised $10.0M Series A in February 2020.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Feb 1, 2020 | $10.0M Series A | Acton Capital Partners, Founders Fund, Presight Capital, Rethink Ventures, Thiel Capital, Valar Ventures | |
| Mar 1, 2019 | $2.0M Seed | Calm/Storm Ventures, Thiel Capital, Tom Williams |