Electra Therapeutics is a technology company.
Electra Therapeutics has raised $264.0M across 2 funding rounds.
Electra Therapeutics has raised $264.0M in total across 2 funding rounds.
Electra Therapeutics is a clinical-stage biotechnology company developing first-in-class therapies targeting signal regulatory proteins (SIRP) on immune cells to selectively deplete pathological myeloid cells and T lymphocytes, addressing unmet needs in immunological diseases and cancer[1][2][3][5][6]. Its lead candidate, ELA026, a monoclonal antibody, is in a pivotal Phase 2/3 trial (SURPASS study) for secondary hemophagocytic lymphohistiocytosis (sHLH), a life-threatening inflammatory disorder, and has received FDA Breakthrough Therapy and EMA PRIME designations; the pipeline also includes preclinical programs like ELA822 for broader immunology and inflammation[2][4][5][6]. The company serves patients with severe inflammatory diseases (e.g., sHLH linked to cancer or rheumatological conditions) and potential expansions into blood cancers, Type 1 diabetes, multiple sclerosis, and celiac disease, solving the problem of uncontrolled myeloid and T cell-driven inflammation where current treatments fall short[3][4][6]. Growth momentum is strong, evidenced by $84M Series B (2022), $183M Series C (recent), and rapid advancement from idea to clinic in under three years[2][4][6].
Electra Therapeutics originated in 2018 as a subsidiary under Star Therapeutics' hub-and-spoke model, leveraging antibody drug discovery expertise to target rare diseases, with an initial focus on a single SIRP program[4][7]. Co-founded by Adam Rosenthal, PhD (initial CEO), the idea emerged from pioneering a novel SIRP-targeting mechanism to deplete pathological immune cells, distinct from traditional CD47/SIRPα checkpoints[1][2]. Pivotal early traction included spinning out as operationally independent in 2023, advancing ELA026 to Phase 1b by presenting safety data in cancer-associated sHLH (100% 8-week survival vs. ~50% historical), and securing Series B funding; leadership transitioned to Kathy Dong, PharmD, MBA (current President and CEO) with deep commercialization experience from Gilead's Sovaldi and Harvoni[2][4][6][7].
Electra stands out in biotech through its SIRP-targeted platform, validated clinically for immune modulation:
Electra rides the wave of precision immunology, targeting myeloid/T cell dysregulation in a growing sHLH population amid rising cancer and autoimmune incidences, where treatments lag (e.g., ~50% survival benchmarks)[4][5][6]. Timing aligns with post-pandemic emphasis on rapid rare disease therapies, bolstered by FDA/EMA fast-tracks amid biotech funding recovery for validated assets[5]. Market forces favor it: expanding immuno-oncology/immunology pipelines, unmet needs in hyperinflammatory syndromes, and SIRP's broad applicability across I&I and cancer, positioning Electra to influence ecosystem shifts toward cell-selective depletors over non-specific drugs[1][3][4]. As a Star Therapeutics spinout, it exemplifies efficient biotech incubation models accelerating novel biology to patients[7].
Electra's trajectory points to ELA026 readouts from SURPASS-1 (sHLH) in 2026, potential approvals by 2028 leveraging designations, and ELA822 IND filing soon after, expanding into high-prevalence I&I like MS[4][5][6]. Trends like AI-driven target validation and combo immuno-therapies will amplify SIRP's role, while commercial expertise (e.g., Dong's track record) ensures launch readiness despite years from market. Electra could redefine myeloid-targeting standards, evolving from sHLH pioneer to immunology leader—grounded in science, as its rigorous novel targets pave breakthrough paths[1][6].
Electra Therapeutics has raised $264.0M in total across 2 funding rounds.
Electra Therapeutics's investors include OrbiMed, Westlake Village BioPartners.
Electra Therapeutics has raised $264.0M across 2 funding rounds. Most recently, it raised $180.0M Series C in October 2025.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Oct 1, 2025 | $180.0M Series C | OrbiMed, Westlake Village BioPartners | |
| Feb 1, 2022 | $84.0M Series B | OrbiMed, Westlake Village BioPartners |