Crinetics Pharmaceuticals is a technology company.
Crinetics Pharmaceuticals has raised $64.0M across 1 funding round.
Crinetics Pharmaceuticals has raised $64.0M in total across 1 funding round.
Crinetics Pharmaceuticals has raised $64.0M in total across 1 funding round.
Crinetics Pharmaceuticals's investors include Cincy Tech, Vivo Capital.
Crinetics Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel oral therapeutics for endocrine diseases and endocrine-related tumors, such as acromegaly, congenital adrenal hyperplasia (CAH), Cushing’s syndrome, and neuroendocrine tumors (NETs).[1][2][3] It serves patients with rare endocrine disorders by addressing unmet needs through small-molecule drugs targeting G-protein-coupled receptors (GPCRs), with a pipeline including lead candidate paltusotine (Phase III for acromegaly) and emerging programs like atumelnant for CAH and CRN09682 nonpeptide drug conjugates (NDCs) for SST2+ tumors.[1][3][4] The company solves problems of inadequate disease control with current injectables by offering simpler, daily oral therapies, showing growth momentum via recent IPO (2018), ongoing Phase III trials (2021-2024), and first patients dosed in new pivotal trials as of late 2025.[1][4]
Headquartered in San Diego, Crinetics emphasizes biomarker-driven discovery to boost clinical success, with 10 disclosed programs across endocrinology, oncology overlaps, and areas like hyperparathyroidism, Graves’ disease, polycystic kidney disease, and obesity.[2][3]
Crinetics was founded in 2008 by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz—scientists with prior collaboration at Neurocrine Biosciences on a small-molecule drug for endometriosis.[1][3] The idea emerged from their expertise in endocrinology, GPCR biology, and medicinal chemistry, aiming to pioneer oral treatments for endocrine disorders underserved by injectables.[1][3]
Early milestones included expanding labs in 2010 with NIH grants, synthesizing lead candidate paltusotine for acromegaly in 2016, and going public via NASDAQ IPO in 2018.[1] Pivotal traction came from Phase II trials (2019-2020) and Phase III for paltusotine (2021-2024), building a fully owned pipeline while growing a world-class R&D team.[1][3]
Crinetics rides the wave of precision endocrinology, where GPCR-targeted small molecules meet rising demand for oral alternatives to biologics in rare diseases like acromegaly (affecting ~20,000 US patients) and CAH.[1][3] Timing aligns with post-2020 biotech funding resurgence and regulatory pushes for orphan drugs, amplified by obesity/endocrine oncology trends amid GLP-1 successes.[3]
Market forces favor it: aging populations boost endocrine disorders, while NDCs offer advantages over antibody-drug conjugates in tumor targeting.[1][3] Crinetics influences the ecosystem by validating endocrine-oncology intersections, inspiring GPCR innovation, and partnering patients/clinicians early—potentially reshaping treatment paradigms as Phase III readouts approach.[2][4]
Crinetics is poised for inflection with paltusotine Phase III data potentially yielding 2026 approval, alongside atumelnant CAH trials and CRN09682 oncology expansion—targeting blockbuster potential in underserved markets.[1][4] Trends like AI-accelerated discovery and endocrine-obesity convergence will shape it, with NDC platform enabling broader oncology forays.[3]
Its influence may evolve from pipeline pioneer to commercial leader, building the "world’s leading endocrine company" via disciplined execution—transforming patient lives as promised since 2008.[2][5]
Crinetics Pharmaceuticals has raised $64.0M across 1 funding round. Most recently, it raised $64.0M Series B in March 2018.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Mar 1, 2018 | $64.0M Series B | Cincy Tech, Vivo Capital |