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biotechnology company developing exosome-based therapeutics by engineering exosomes for oncology and other diseases.
Codiak Biosciences has raised $217.5M across 3 funding rounds.
Key people at Codiak Biosciences.
Codiak Biosciences was founded in 2015 by Phillip Samayoa (Co-Founder).
Codiak Biosciences has raised $217.5M in total across 3 funding rounds.
Based in Boston, Massachusetts, Codiak BioSciences is a biotechnology company that engineers naturally occurring exosomes to deliver therapeutic payloads like DNA, RNA, and proteins to specific target cells. The organization focuses on developing exosome-based therapeutics and diagnostics for oncology and other diseases with high unmet medical needs, notably collaborating with the MD Anderson Cancer Center. Prior to its public market delisting, the enterprise secured significant private capital, including an initial $80 million across Series A and B rounds, followed by a $76.5 million Series C financing. Despite backing from prominent lead investors ARCH Venture Partners and Flagship Ventures, the company recently experienced a severe valuation decline, resulting in a market capitalization of just $58,900. Codiak BioSciences was originally founded in 2015 by scientific co-founders Eric Lander and Raghu Kalluri alongside founding chief executive officer Douglas E. Williams.
Codiak BioSciences is a clinical-stage biopharmaceutical company pioneering exosome-based therapeutics to treat diseases with high unmet needs, including cancer, infectious diseases, and chronic conditions.[2][3][4] It develops its proprietary engEx™ platform to engineer exosomes—natural cell-derived vesicles—for targeted delivery of therapeutics like antigens, adjuvants, and antisense oligonucleotides, creating a pipeline for oncology, immunotherapy, and vaccines such as exoVACC for betacoronaviruses.[2][3][5][6] The company serves patients with hard-to-treat conditions by addressing limitations in traditional drug delivery, such as poor cytoplasmic access and immune response durability, with early preclinical traction in solid tumors, glioma, and HIV.[2][6]
Codiak BioSciences was launched in 2015 through a collaboration between ARCH Venture Partners, Flagship Ventures (now Flagship Pioneering), and MD Anderson Cancer Center, focusing on harnessing exosomes for therapeutics and diagnostics in cancer and other diseases.[7] This venture-backed startup emerged from scientific ambition to leverage exosomes' natural role in intercellular communication, building a broad platform for macromolecule delivery to diverse cells and tissues.[5][7] Early milestones included preclinical data on vaccine candidates like exoVACC, showing durable immune responses against SARS-CoV-2 variants, and partnerships such as with CEPI in 2022 to advance betacoronavirus vaccines.[2]
Codiak rides the exosome therapeutics trend, a emerging class of biologics capitalizing on vesicle-based drug delivery amid rising demand for precise, multifunctional treatments in oncology and infectious diseases.[2][4] Timing aligns with post-COVID advances in mRNA and nanoparticle vaccines, where exosomes offer advantages in stability and targeting over lipid nanoparticles.[2] Market forces like high failure rates in cytokine therapies (e.g., IL-12) and need for durable vaccines favor its platform, influencing the ecosystem by validating exosomes as a "major shift" in medicine and inspiring similar biotech innovations.[4][6][7]
Codiak's trajectory hinges on resurrecting or partnering its engEx™ assets, potentially in oncology or next-gen vaccines, as many pipeline programs were discontinued post-preclinical phases.[6] Trends like AI-driven exosome engineering and combo immunotherapies could revitalize its momentum, evolving its role from pioneer to key player in regenerative biotech. As an early innovator in a nascent field, its foundational IP positions it to shape exosome standards, tying back to its mission of transforming high-need disease treatment through biological ingenuity.[3][4]
Key people at Codiak Biosciences.
Codiak Biosciences was founded in 2015 by Phillip Samayoa (Co-Founder).
Codiak Biosciences has raised $217.5M in total across 3 funding rounds.
Codiak Biosciences's investors include Alaska Permanent Fund, Alexandria Venture Investments, ARCH Venture Partners, Boxer Capital, Casdin Capital, EcoR1 Capital, Fidelity Management & Research Company, Flagship Pioneering, Qatar Investment Authority, Sirona Capital, Flagship Ventures, Codiak BioSciences.
Codiak Biosciences has raised $217.5M across 3 funding rounds. Most recently, it raised $76.5M Series C in November 2017.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Nov 29, 2017 | $76.5M Series C | — | Alaska Permanent Fund, Alexandria Venture Investments, ARCH Venture Partners, Boxer Capital, Casdin Capital, EcoR1 Capital, Fidelity Management & Research Company, Flagship Pioneering, Qatar Investment Authority, Sirona Capital | Announced |
| Jan 26, 2016 | $61M Series B | ARCH Venture Partners, Flagship Ventures | Alaska Permanent Fund, Alexandria Venture Investments, Codiak BioSciences, Fidelity Management & Research Company | Announced |
| Nov 17, 2015 | $80M Series A | Steven Gillis, Noubar Afeyan | Alaska Permanent Fund, Alexandria Venture Investments, Fidelity Management & Research Company | Announced |