Casma Therapeutics is a technology company.
Casma Therapeutics has raised $155.0M across 3 funding rounds.
Casma Therapeutics has raised $155.0M in total across 3 funding rounds.
Casma Therapeutics is a biotechnology company developing therapeutics that reprogram the autophagy pathway—a natural cellular process for degrading damaged components—to target diseases like neurodegeneration, lysosomal storage disorders, liver and muscle diseases, and inflammation.[1][2][3][4] Headquartered in Cambridge, MA, and founded in 2018, it serves patients with unmet needs in these areas by engineering selective degradation of disease-causing elements via its PHLYT™ platform (Phagosome-Lysosome Targeting), which enables permanent elimination of complex cellular targets beyond traditional protein degraders.[1][4] The company has shown growth momentum through a $58.5M Series A in 2018, a $46M Series C in 2022, and nomination of its first development candidate, CSM-101 (a TRPML1 agonist for Parkinson's disease), in June 2025.[2][5][6]
Casma was launched in May 2018 by Third Rock Ventures with $58.5 million in Series A funding, capitalizing on emerging insights into autophagy's role in cellular health and disease.[2] CEO Keith Dionne, a serial biotech entrepreneur with over 20 years of experience leading three prior companies, led the effort alongside Leon Murphy, SVP of Biology and an autophagy expert from Novartis.[2] The idea stemmed from deep expertise in cell biology, aiming to intervene at strategic points in autophagy to clear unwanted proteins, organelles, and pathogens—addressing diseases where traditional drugs fall short.[1][2][3] Early preclinical data validated this approach across multiple indications, setting the stage for platform expansion.[2]
Casma rides the wave of targeted protein degradation and lysosomal biology, trends exploding as new modalities like autophagy inducers address limitations of small molecules and gene therapies in neurodegeneration and rare diseases.[1][2][4][6] Timing aligns with 2020s advances in understanding autophagy's dysfunction in aging-related conditions like Parkinson's, amplified by market forces such as rising neurodegenerative prevalence and investor interest in novel engines (evidenced by Series C from Amgen Ventures, Astellas, and others).[6] By pioneering autophagy reprogramming, Casma influences the ecosystem, expanding the "druggable" proteome and inspiring platforms that integrate lysosomal targeting for harder-to-treat indications.[3][4]
Casma's nomination of CSM-101 positions it for IND filing and clinical trials in Parkinson's by late 2026, potentially validating PHLYT™ across neurodegeneration and lysosomal disorders.[6] Trends like AI-driven target ID and combo therapies with degraders will accelerate its pipeline, while partnerships (hinted via recent investors) could fuel expansion into inflammation and muscle diseases.[6] As autophagy moves mainstream, Casma's influence may grow through first-mover data, bridging cellular quality control to transformative medicines and redefining biotech's approach to cellular damage. This builds on its mission to eliminate what current drugs cannot.[1][4]
Casma Therapeutics has raised $155.0M in total across 3 funding rounds.
Casma Therapeutics's investors include Astellas Venture Management, The Column Group, Third Rock Ventures.
Casma Therapeutics has raised $155.0M across 3 funding rounds. Most recently, it raised $46.0M Series C in November 2022.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Nov 1, 2022 | $46.0M Series C | Astellas Venture Management, The Column Group, Third Rock Ventures | |
| Sep 1, 2020 | $50.0M Series B | Astellas Venture Management, The Column Group, Third Rock Ventures | |
| May 1, 2018 | $59.0M Series A | Astellas Venture Management, The Column Group, Third Rock Ventures |