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Bloom Science is a San Diego, California-based clinical-stage biotechnology company that develops live biotherapeutic products and genetically optimized living medicines for severe metabolic and neurological disorders. The organization utilizes its synthetic biology platform to engineer microbiota therapeutics targeting the gut-brain axis, specifically aiming to replicate the clinical efficacy of ketogenic diets with improved safety profiles. Its primary therapeutic pipeline focuses on addressing complex and rare diseases across immunology and neurology, including obesity, Dravet syndrome, rare epilepsies, amyotrophic lateral sclerosis, and cardiometabolic conditions. The enterprise has successfully raised $12 million in total venture funding through a Series A financing round backed by institutional investors such as Social Starts, Apollo Health Ventures, ALS Investment Fund, and Leaps by Bayer. Bloom Science was officially established in 2018 by founding team members Christopher Reyes, Elaine Hsiao, and Raphael Valdivia.
Bloom Science has raised $12.0M across 1 funding round.
Bloom Science has raised $12.0M in total across 1 funding round.
Bloom Science has raised $12.0M across 1 funding round. Most recently, it raised $12.0M Series A in December 2021.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Dec 1, 2021 | $12M Series A | ALS Investment Fund, Leaps BY Bayer | Apollo Health Ventures, Joyance Partners | Announced |
Bloom Science is a San Diego-based clinical-stage biotechnology company developing live biotherapeutics that harness the gut microbiome to treat unmet needs in neurological and metabolic disorders.[1][2][3] It targets the gut-immune-brain axis using its proprietary IrisRx drug discovery platform, which reverse-translates clinical treatments like the ketogenic diet into microbiome-based therapies.[1][2] The lead product, BL-001, replicates ketogenic diet benefits for obesity and Dravet syndrome (a rare epilepsy), having completed Phase 1 trials showing safety, tolerability, proof-of-mechanism, and weight loss in overweight subjects; Phase 2 trials are planned.[2][3] Initial programs also address ALS and drug-resistant epilepsy, serving patients with severe neurological and inflammatory conditions lacking effective options.[1][3] In 2023, Bloom raised $12M in Series A funding led by Leaps by Bayer and ALS Investment Fund, fueling pipeline advancement.[1]
Bloom Science was founded by Christopher Reyes, PhD, its CEO, driven by a vision to exploit the gut-immune-brain axis for untreatable neurological and inflammatory diseases.[1] The company emerged from insights into the microbiome's role in modulating brain and immune functions, rethinking drug development through live biotherapeutics.[1][2] Early milestones include building the IrisRx platform for candidate screening, preclinical validation of BL-001's anti-epileptic effects (inspired by ketogenic diet research spanning 100 years), and Phase 0 reverse fecal microbiota transplantation confirming efficacy in animal models.[3] Phase 1 trials in healthy volunteers reported no serious adverse events, mirroring mild ketogenic diet side effects, while also demonstrating dose-dependent metabolic changes and weight loss.[3] This traction secured the $12M Series A in 2023 from investors like Leaps by Bayer, Apollo Health Ventures, and Joyance Partners.[1]
Bloom Science rides the exploding microbiome therapeutics wave, fueled by growing evidence of gut microbes' influence on neurology and metabolism amid rising obesity (global epidemic) and rare diseases like Dravet syndrome and ALS (limited treatments).[1][2][3] Timing aligns with synthetic biology advances and post-ketogenic diet research, enabling scalable, oral biotherapeutics over restrictive diets or invasive drugs.[2][3] Market tailwinds include surging investor interest in gut-brain axis (e.g., Bayer's Leaps backing) and regulatory nods for live biotherapeutics, with Bloom's Phase 1 data de-risking the field.[1][3] It influences biotech by validating reverse-translation platforms, potentially expanding microbiome applications to neurodegeneration and inflammation, accelerating ecosystem-wide innovation in precision medicine.[1][2]
Bloom Science is poised for Phase 2 readouts on BL-001 in obesity and Dravet syndrome, potentially unlocking blockbuster markets while validating IrisRx for ALS and beyond.[2][3] Trends like AI-driven microbiome mapping and combination therapies with immunotherapeutics will amplify its edge, though execution risks in late-stage trials and manufacturing scale remain.[3] Its influence could grow by partnering with big pharma (e.g., Bayer synergies) to mainstream gut-brain treatments, transforming outcomes for millions—echoing its founding mission to exponentially expand therapy options via the body's natural pathways.[1][2]
Bloom Science has raised $12.0M in total across 1 funding round.
Bloom Science's investors include ALS Investment Fund, Leaps by Bayer, Apollo Health Ventures, Joyance Partners.
