BioRefine is a technology company.
BioRefine has raised $230K across 1 funding round.
BioRefine has raised $230K in total across 1 funding round.
BioReFine is an Israeli medical device company developing innovative technologies in interventional structural cardiology. It builds a unique endovascular annuloplasty remodeling system that repairs mitral and tricuspid heart valves without implants, targeting patients with valvular heart disease.[2][3] The product serves cardiologists and patients suffering from conditions like mitral and tricuspid regurgitation, solving the problem of ineffective or invasive valve repairs by offering a less invasive, implant-free alternative that remodels valve annuli endovascularly.[2][3] As a portfolio company of Peregrine VC, it demonstrates growth momentum through venture backing and focus on high-need cardiac interventions.[3]
Note: Search results also reference "BioRefine Cluster Europe," a non-profit network for biobased resource recovery projects, but the query specifies a "technology company," aligning with BioReFine Ltd.'s profile as a for-profit medtech innovator.[1][2]
BioReFine emerged from Israel's vibrant medtech ecosystem, founded by experts in interventional cardiology seeking to address limitations in transcatheter valve repair. While specific founder names and exact founding year are not detailed in available sources, the company quickly gained traction as a Peregrine VC portfolio company, highlighting early validation of its implant-free annuloplasty technology.[3] A pivotal moment was developing its core system for mitral and tricuspid repair, filling a gap in non-implant solutions amid rising demand for minimally invasive cardiac procedures.[2][3]
BioReFine rides the wave of transcatheter structural heart interventions, a booming segment driven by aging populations and rising heart valve disease prevalence. Timing is ideal amid trends like TAVR/TEER expansion, where implant-free options counter device-related risks highlighted in recent trials.[2][3] Favorable market forces include regulatory tailwinds for next-gen devices (e.g., FDA breakthroughs in non-implant tech) and investor interest in Israeli medtech, which excels in cardiology innovation. It influences the ecosystem by pushing boundaries toward fully reversible repairs, potentially lowering healthcare costs and inspiring hybrid bio-mechanical solutions.
BioReFine is poised for clinical trials and first-in-human data in 2026, leveraging its differentiated tech to capture share in the $10B+ structural heart market. Trends like AI-guided imaging and outpatient procedures will accelerate adoption, while partnerships could fast-track CE Mark/FDA approval. Its influence may evolve from niche innovator to category leader, redefining valve repair as we know it—bridging the gap from high-level promise to transformative patient impact.
BioRefine has raised $230K in total across 1 funding round.
BioRefine's investors include Peregrine Ventures.
BioRefine has raised $230K across 1 funding round. Most recently, it raised $230K Seed in July 2019.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Jul 1, 2019 | $230K Seed | Peregrine Ventures |