Astria Therapeutics is a technology company.
Astria Therapeutics has raised $103.0M across 5 funding rounds.
Astria Therapeutics has raised $103.0M in total across 5 funding rounds.
Astria Therapeutics has raised $103.0M in total across 5 funding rounds.
Astria Therapeutics's investors include Advanced Technology Ventures, OrbiMed, Polaris Partners, Venrock.
Astria Therapeutics is a biopharmaceutical company developing monoclonal antibody therapies for rare and niche allergic and immunological diseases, primarily targeting hereditary angioedema (HAE) and atopic dermatitis.[1][2][4] Its lead candidate, navenibart (STAR-0215), a plasma kallikrein inhibitor, is in Phase 1b/2 trials for HAE prevention, offering potential as a long-acting, patient-friendly prophylactic treatment, while STAR-0310, an OX40 antagonist, advances for atopic dermatitis.[2][5] Headquartered in Boston with 78 employees, the company serves patients facing debilitating attacks from these conditions, addressing unmet needs in chronic management through discovery, development, and commercialization.[1][2]
Founded in 2008 and publicly traded (Nasdaq: ATXS) since 2015, Astria shows growth momentum via positive initial proof-of-concept data from the ALPHA-STAR trial for STAR-0215 and a pipeline expansion in allergy/immunology, bolstered by a 2021 pivot and $110 million financing.[2][3][4]
Astria Therapeutics traces its roots to 2008, when it was incorporated as Catabasis Pharmaceuticals, initially focused on other therapeutic areas before rebranding to Astria in September 2021 following the acquisition of Quellis Biosciences in January 2021.[2][3] This strategic shift refocused the company on allergy and immunology, particularly rare diseases like HAE, with co-founder and CEO Jill C. Milne, Ph.D., leading the vision of patient-guided innovation.[2][3]
The idea emerged from patient needs in underserved areas, propelled by the Quellis deal and private placement funding to advance STAR-0215 toward an IND filing in mid-2022 and Phase 1 trials later that year; early traction includes preclinical progress and recent clinical proof-of-concept results, humanizing the mission through stories of HAE patients like Melissa, Hannah, and Kim.[3][4]
Astria rides the wave of precision immunology in biotech, capitalizing on monoclonal antibody advances for rare diseases amid rising demand for targeted HAE therapies, where current options burden patients with frequent dosing.[1][2][3] Timing aligns with post-2021 funding enabling Phase 1b/2 progress by 2025, fueled by market forces like orphan drug incentives and growing HAE prevalence awareness.[3][4]
In the healthcare ecosystem, Astria influences by expanding pipelines through internal discovery and partnerships, contributing to Massachusetts' biotech hub while advocating patient transparency, potentially shaping standards for niche allergic treatments.[1][2][4]
Astria's trajectory points to pivotal readouts from ALPHA-STAR and STAR-0310 trials, with potential regulatory milestones for STAR-0215 positioning it as a differentiated HAE leader amid competition.[2][4][5] Trends like antibody engineering and patient advocacy will propel growth, evolving Astria's influence toward a broader immunology portfolio via licensing.
This patient-star-guided biotech exemplifies how science meets compassion in rare disease innovation, echoing its opening mission to transform lives in allergy and immunology.[1][4]
Astria Therapeutics has raised $103.0M across 5 funding rounds. Most recently, it raised $32.0M Series B in November 2013.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Nov 1, 2013 | $32.0M Series B | Advanced Technology Ventures, OrbiMed, Polaris Partners, Venrock | |
| Feb 1, 2013 | $9.0M Venture Round | Advanced Technology Ventures, OrbiMed, Polaris Partners, Venrock | |
| Dec 1, 2011 | $8.0M Series A | Advanced Technology Ventures, OrbiMed, Polaris Partners, Venrock | |
| Dec 1, 2010 | $15.0M Series A | Advanced Technology Ventures, OrbiMed, Polaris Partners, Venrock | |
| Apr 1, 2010 | $39.0M Series A | Advanced Technology Ventures, OrbiMed, Polaris Partners, Venrock |