Affini-T Therapeutics is a technology company.
Affini-T Therapeutics has raised $180.0M across 1 funding round.
Affini-T Therapeutics has raised $180.0M in total across 1 funding round.
Affini-T Therapeutics has raised $180.0M in total across 1 funding round.
Affini-T Therapeutics's investors include Vida Ventures.
Affini-T Therapeutics is a clinical-stage biotechnology company developing TCR-based immunotherapies for solid tumors, targeting oncogenic driver mutations like KRAS to create potentially curative treatments.[1][2][5][6] It builds autologous TCR-T cell therapies and bispecific T cell engagers using platforms that integrate high-throughput screening, synthetic biology, and gene editing to overcome immunosuppressive tumor microenvironments and address hard-to-treat cancers such as lung, colorectal, and pancreatic.[1][4][5][6] The company serves patients with solid tumors driven by mutations like KRAS (up to 30% of cancers) and TP53, solving the lack of durable therapies by engineering T cells for precise, persistent anti-tumor responses.[4][5][6] Affini-T has shown growth momentum through a $175 million financing in 2024 co-led by Vida Ventures and Leaps by Bayer, partnerships like with ElevateBio for manufacturing, and presentations of preclinical and trial-in-progress data targeting KRAS G12D/V and TP53 R175H as of 2025.[4][5][6][8]
Affini-T Therapeutics was founded by Arjun Goyal and Jak Knowles, M.D., who brought proven expertise in immune cell therapies and innovation.[1][6][9] Jak Knowles serves as Co-Founder, President, and CEO, emphasizing the company's focus on striking core genetic mutations like mutated KRAS to eradicate solid tumors.[6] The idea emerged from recognizing hurdles in cellular engineering for solid tumors, leading to validated platforms that leverage synthetic biology and gene editing—technologies the co-founders advanced to enable therapies previously unfeasible.[1][2] Early traction included building a world-class team of immunology and cellular engineering leaders, securing significant funding, and advancing to clinical-stage programs, with pivotal moments like the 2024 financing and 2025 data presentations at conferences.[5][6][8]
Affini-T rides the wave of precision immunotherapy in oncology, capitalizing on advances in synthetic biology and gene editing to tackle solid tumors—where traditional therapies fail due to immunosuppressive microenvironments.[1][2][5] Timing aligns with surging demand for KRAS-targeted treatments, as these mutations drive 30% of cancers with high mortality, and recent tools like non-viral editing enable breakthroughs long stalled by technical hurdles.[4][6] Market forces favoring it include massive biotech investments in cell therapies (e.g., $175M raise) and regulatory momentum for mutant-specific approaches, positioning Affini-T to influence the ecosystem by validating TCR platforms for "hard-to-treat" indications and potentially setting standards for curative solid tumor therapies.[5][6][8]
Affini-T is poised to advance its lead KRAS programs into deeper clinical trials, with upcoming data readouts from trial-in-progress posters and presentations like at the 2025 J.P. Morgan Healthcare Conference signaling near-term catalysts.[5][8] Trends in AI-enhanced engineering, non-viral editing, and combination immunotherapies will amplify its platforms, potentially expanding to more drivers beyond KRAS/TP53. Its influence may evolve from pioneer to category leader in solid tumor cures, delivering durable responses that reshape oncology standards and attract further big-pharma partnerships, fulfilling its mission to transform patient outcomes in intractable cancers.[1][5][6]
Affini-T Therapeutics has raised $180.0M across 1 funding round. Most recently, it raised $180.0M Venture Round in March 2022.
| Date | Round | Lead Investors | Other Investors |
|---|---|---|---|
| Mar 1, 2022 | $180.0M Venture Round | Vida Ventures |